EC Number   |
Activating Compound |
Reference |
|---|
    1.1.98.6 | ATP |
1.5 mM, 500fold increase in reduction rate of CTP, 2.5fold increase for GTP |
740670 |
| 1.1.98.6 | ATP |
positive effector for CTP reduction |
740665 |
| 1.1.98.6 | ATP |
strong stimulation |
740651 |
| 1.1.98.6 | dATP |
positive effector for CTP reduction |
740665 |
| 1.1.98.6 | dGTP |
1.5 mM, 20fold increase in reduction rate of ATP |
740670 |
| 1.1.98.6 | dGTP |
positive effector for ATP reduction |
740665 |
| 1.1.98.6 | dTTP |
1.5 mM, 3fold increase in reduction rate of GTP |
740670 |
| 1.1.98.6 | dTTP |
positive effector for GTP reduction |
740665 |
| 1.1.98.6 | more |
allosteric effectors bind to two separate sites on NrdD, one binding dATP, dGTP, and dTTP and the other binding dATP and ATP. The two sites show an unusually high degree of cooperativity with complex interactions between effectors and a fine-tuning of their physiological effects |
740670 |
| 1.1.98.6 | more |
enzyme has a single type of allosteric site to which dGTP, dTTP, dATP, and ATP bind competitively |
740665 |
