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EC Number
Activating Compound
Commentary
Reference
1.14.11.27
ascorbate
required for optimal activity
662947
1.14.11.27
ascorbate
stimulation
688966
1.14.11.27
fisetin
fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP targets KDM4A. Overexpression of RFXAP upregulates KDM4A and attenuates methylation of H3K36, impairing DNA repair and enhancing the DNA damage induced by fisetin
764436
1.14.11.27
HP1a
H3K36 demethylation activity of the fly dKDM4A is dramatically stimulated upon HP1a association
701212
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