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EC Number Activating Compound Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.66ascorbate - 744722, 752643
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.66ascorbate required 753157
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.66ascorbate required for activity 745917
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.66fisetin fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP targets KDM4A. Overexpression of RFXAP upregulates KDM4A and attenuates methylation of H3K36, impairing DNA repair and enhancing the DNA damage induced by fisetin 764436
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.66more RNA interaction with KDM4D N-terminus is essential for KDM4D association with chromatin 745917
Display the word mapDisplay the reaction diagram Show all sequences 1.14.11.66more transient hyperglycemia induces recruitment of LSD1 to gene regulation sites/promoters 697557
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