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EC Number
Activating Compound
Commentary
Reference
1.14.11.66
ascorbate
-
744722
,
752643
1.14.11.66
ascorbate
required
753157
1.14.11.66
ascorbate
required for activity
745917
1.14.11.66
fisetin
fisetin induces DNA damage via critical transcription factor RFXAP/KDM4A-dependent histone H3K36 demethylation, thus causing inhibition of proliferation in pancreatic adenocarcinoma (PDAC). Fisetin inhibits cell proliferation and induces DNA damage and S-phase arrest in PDAC. Expression of RFXAP and other DNA-damage response genes is upregulated by fisetin. RFXAP targets KDM4A. Overexpression of RFXAP upregulates KDM4A and attenuates methylation of H3K36, impairing DNA repair and enhancing the DNA damage induced by fisetin
764436
1.14.11.66
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RNA interaction with KDM4D N-terminus is essential for KDM4D association with chromatin
745917
1.14.11.66
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transient hyperglycemia induces recruitment of LSD1 to gene regulation sites/promoters
697557
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