EC Number   |
Activating Compound |
Reference |
|---|
    1.3.1.72 | cholesterol |
high levels of DHCR24 are associated with elevated cholesterol concentrations |
688975 |
| 1.3.1.72 | cholestyramine |
120fold induction and activation by feeding 5% cholestyramine plus 0.1% lovastatin, CL-diet, and by modulating diurnal variation |
288496 |
| 1.3.1.72 | CO |
substrate lanosterol: required to inhibit 14alpha-methyl demethylase, 14alpha-demethylation of lanosterol. 14alpha-methyl demethylase activity is dominant over 24-reductase activity, and blockade or removal of 14alpha-methyl demethylase activity is absolutely required for the detection of maximal 24-reductase activity when lanosterol substrate is present. 24-reductase activity is activated in time-dependent manner when 14alpha-methyl demethylase is blocked by CO treatment |
288496 |
| 1.3.1.72 | FAD |
activate 2fold when added to the assay |
654165 |
| 1.3.1.72 | H2O2 |
DHCR24 mRNA levels increase in response to oxidative stress (0.1 mM H2O2) in a time-dependent manner, reaching the maximum after 4 h |
688975 |
| 1.3.1.72 | ketoconazole |
substrate lanosterol: dose-dependent activation, less effective than miconazole, required to inhibit 14alpha-methyl demethylase, 14alpha-demethylation of lanosterol. 14alpha-methyl demethylase activity is dominant over 24-reductase activity, and blockade or removal of 14alpha-methyl demethylase activity is absolutely required for the detection of maximal 24-reductase activity when lanosterol substrate is present |
288496 |
| 1.3.1.72 | lovastatin |
120fold induction and activation by feeding 5% cholestyramine plus 0.1% lovastatin, CL-diet, and by modulating diurnal variation |
288496 |
| 1.3.1.72 | miconazole |
substrate lanosterol: dose-dependent activation, maximum activation with about 0.01 mM miconazole, required to inhibit 14alpha-methyl demethylase, 14alpha-demethylation of lanosterol. 14alpha-methyl demethylase activity is dominant over 24-reductase activity, and blockade or removal of 14alpha-methyl demethylase activity is absolutely required for the detection of maximal 24-reductase activity when lanosterol substrate is present |
288496 |
