EC Number   |
Inhibitors |
Structure |
|---|
    2.5.1.72 | 1,10-phenanthroline |
inhibits reactivation of O2-inactivated enzyme |
   |
| 2.5.1.72 | 2,2'-dipyridyl |
inhibits reactivation of O2-inactivated enzyme |
|
| 2.5.1.72 | 4,5-dithiohydroxyphthalic acid |
structural analogue of the 5-hydroxy-4,5-dihydropyridine-2,3-dicarboxylic acid intermediate. Compound coordinates to the enzyme [4Fe-4S] cluster through a differentiated iron site, thus leading to the inhibition of quinolate formation. Compound is inhibitory in vitro and in vivo |
|
| 2.5.1.72 | 4-mercaptophthalic acid |
- |
|
| 2.5.1.72 | 5-mercaptopyrazine-2,3-dicarboxylic acid |
- |
|
| 2.5.1.72 | 6-mercaptopyridine-2,3-dicarboxylic acid |
- |
|
| 2.5.1.72 | H2O2 |
1 mM, inactivation |
|
| 2.5.1.72 | O2 |
the activity of the enzyme within Escherichia coli is diminished by exposure of the cells to 4.2 atm O2, while the activity in extracts is rapidly decreased by 0.2 atm O2. Inactivation in extracts can be gradually reversed during anaerobic incubation, but is blocked by alpha, alpha'-dipyridyl or by 1,10-phenanthroline |
|
| 2.5.1.72 | O2 |
complete loss of activity upon purification of enzyme in aerobic conditions or exposure to oxygen overnight |
|
| 2.5.1.72 | paraquat |
inactivation |
|
