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EC Number
Inhibitors
Commentary
Structure
3.1.26.3
2-hydroxyisoquinoline-1,3-dione
inhibits cleavage of R1.1 RNA, IC50: 0.014 mM for Mg2+-supported reaction, 0.008 mM for Mn2+-suppoeted reaction, noncompetitive inhibition
3.1.26.3
2-mercaptoethanol
required
3.1.26.3
Ca2+
recombinant Sa-RNase III is inhibited by Ca2+
3.1.26.3
Co2+
-
3.1.26.3
Cu2+
-
3.1.26.3
Double-stranded RNA
inhibits cleavage of single-stranded RNA
3.1.26.3
EDTA
-
3.1.26.3
EDTA
greater than 10 mM
3.1.26.3
EDTA
complete inhibition
3.1.26.3
Ethidium bromide
at 1.5 M
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