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EC Number	Localization	Commentary	GeneOntology No.	Reference
6.3.4.3	cytoplasm	-	GO:0005737 AmiGO QuickGO	651414, 701402, 727607
6.3.4.3	cytosol	-	GO:0005829 AmiGO QuickGO	1528, 700281
6.3.4.3	cytosol	ADE3	GO:0005829 AmiGO QuickGO	701402
6.3.4.3	cytosol	trifunctional cytosolic isozyme	GO:0005829 AmiGO QuickGO	662447
6.3.4.3	mitochondrion	-	GO:0005739 AmiGO QuickGO	652471, 701402
6.3.4.3	mitochondrion	mitochondrial C1-THF synthase behaves as a peripheral membrane protein, tightly associated with the matrix side of the mitochondrial inner membrane	GO:0005739 AmiGO QuickGO	690632
6.3.4.3	mitochondrion	mitochondrial isozyme	GO:0005739 AmiGO QuickGO	660817
6.3.4.3	mitochondrion	mitochondrial isozyme, contains an N-terminal mitochondrial targeting sequence	GO:0005739 AmiGO QuickGO	660866
6.3.4.3	mitochondrion	mitochondrial monofunctional isozyme	GO:0005739 AmiGO QuickGO	662447
6.3.4.3	mitochondrion	MTHFD1L enzyme is present in mitochondria from normal embryonic tissues and embryonic fibroblast cell lines, and embryonic mitochondria possess the ability to synthesize formate from glycine. Greater than 75% of 1-C units entering the cytoplasmic methyl cycle are mitochondrially derived	GO:0005739 AmiGO QuickGO	712483

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Release 2023.1 (January 2023)