Search Natural Substrates/ Products (Substrates)

1.7.1.B2

2,4,6-trinitrotoluene + NADH + H+

1.7.1.B2

2,4,6-trinitrotoluene + NADPH + H+

1.7.1.B2

2,4-dinitrotoluene + NADPH + H+

1.7.1.B2

2,4-dinitrotoluene + NADPH + H+

highest activity

1.7.1.B2

2,6-dinitrotoluene + NADPH + H+

1.7.1.B2

2,6-dinitrotoluene + NADPH + H+

highest activity

1.7.1.B2

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Escherichia coli nitroreductase NfsB can reduce nitrochloromethylbenzindolines, i.e. nitro-CBIs, in an oxygen-independent fashion, generating highly cytotoxic metabolites that alkylate the N3 of adenine in the minor groove of DNA

1.7.1.B2

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Pseudomonas aeruginosa nitroreductase NfsB can reduce nitrochloromethylbenzindolines, i.e. nitro-CBIs, in an oxygen-independent fashion, generating highly cytotoxic metabolites that alkylate the N3 of adenine in the minor groove of DNA