EC Number |
Recommended Name |
Natural Substrates |
Organism |
Natural Products |
---|
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
10-formyltetrahydrofolate + NADP+ + H2O |
Rattus norvegicus |
- |
tetrahydrofolate + CO2 + NADPH + H+ |
- |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
10-formyltetrahydrofolate + NADP+ + H2O |
Rattus norvegicus |
natural substrate |
tetrahydrofolate + CO2 + NADPH + H+ |
- |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
10-formyltetrahydrofolate + NADP+ + H2O |
Rattus norvegicus |
recycling of excess 10-formyltetrahydrofolate that is not needed for purine biosynthesis and restoration of the tetrahydrofolate pool, important for formate metabolism by clearing it as CO2 and thus protecting cells from formate intoxication |
tetrahydrofolate + CO2 + NADPH + H+ |
- |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
10-formyltetrahydrofolate + NADP+ + H2O |
Rattus norvegicus |
regulatory mechanism to control the in vivo folate pool size |
tetrahydrofolate + CO2 + NADPH + H+ |
- |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
10-formyltetrahydrofolate + NADP+ + H2O |
Rattus norvegicus |
disposal of excess one-carbon units, oxidation of one-carbon moieties is regulated by the ratio of formyltetrahydrofolate to tetrahydrofolate in liver, regulation of the proportion of folate present in the tetrahydrofolate form, presumably to make it available for other reactions of one-carbon metabolism |
tetrahydrofolate + CO2 + NADPH + H+ |
- |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
10-formyltetrahydrofolate + NADP+ + H2O |
Rattus norvegicus |
folate-dependent metabolism of formate to carbon dioxide |
tetrahydrofolate + CO2 + NADPH + H+ |
- |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
10-formyltetrahydrofolate + NADP+ + H2O |
Rattus norvegicus |
a major folate-binding protein of liver cytosol, 10-formyltetrahydrofolate polyglutamates are tightly bound in vivo |
tetrahydrofolate + CO2 + NADPH + H+ |
- |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
10-formyltetrahydropteroylpentaglutamate + NADP+ + H2O |
Rattus norvegicus |
- |
tetrahydropteroylpentaglutamate + CO2 + NADPH |
- |
1.5.1.6 | formyltetrahydrofolate dehydrogenase |
10-formyltetrahydropteroylpentaglutamate + NADP+ + H2O |
Rattus norvegicus |
natural substrate |
tetrahydropteroylpentaglutamate + CO2 + NADPH |
- |
1.5.1.5 | methylenetetrahydrofolate dehydrogenase (NADP+) |
5,10-methylenetetrahydrofolate + NADP+ |
Rattus norvegicus |
- |
5,10-methenyltetrahydrofolate + NADPH + H+ |
- |