EC Number |
Natural Substrates |
---|
1.1.1.42 | 2-oxoglutarate + CO2 + NADPH + H+ |
- |
1.1.1.42 | D-isocitrate + NADP+ |
enzyme is an integral part of the mitochondrial TCA cycle, and it is involved in providing NADPH for reductive reactions in the cell |
1.1.1.42 | D-isocitrate + NADP+ |
the reaction is reversible for isozyme IDP2 |
1.1.1.42 | D-isocitrate + NADP+ |
- |
1.1.1.42 | DL-isocitrate + NADP+ |
- |
1.1.1.42 | isocitrate + NADP+ |
- |
1.1.1.42 | isocitrate + NADP+ |
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates |
1.1.1.42 | isocitrate + NADP+ |
carbon dioxide-fixing enzyme in the reductive tricarboxylic acid cycle, preference for carboxylation reaction direction |
1.1.1.42 | isocitrate + NADP+ |
cytosolic enzyme is critical in fat and cholesterol biosynthesis, enzyme content correlates with adipogenesis in wild-type adipocytes and in transgenic cells |
1.1.1.42 | isocitrate + NADP+ |
enzyme has a self-regulatory mechanism of activity mimicking the phosphorylation mechanism of bacterial enzymes |