EC Number   |
Natural Substrates |
|---|
   1.1.1.50 | 3-hydroxysteroid + NAD(P)+ |
- |
| 1.1.1.50 | 3alpha,5alpha-allopregnenolone + NAD(P)+ |
i.e. 3alpha,5alpha-tetrahydroprogesterone or 3alpha,5alpha-THP, the enzyme catalyzes the biosynthesis and oxidation of 3alpha,5alpha-reduced neurosteroids as allopregnanolone, which stimulates GABAA receptors, sciatic nerves-induced analgesia results in increased enzyme levels in neuropathic rats, overview |
| 1.1.1.50 | 3alpha-hydroxy-5alpha-pregnan-20-one + NADP+ |
- |
| 1.1.1.50 | 3alpha-hydroxypregn-4-en-20-one + NADP+ |
- |
| 1.1.1.50 | 4-pregnen-3alpha,20beta-diol + NAD+ |
- |
| 1.1.1.50 | 5alpha-dihydroprogesterone + 2 NAD(P)H + 2 H+ |
- |
| 1.1.1.50 | 5alpha-dihydroprogesterone + 2 NADPH + 2 H+ |
- |
| 1.1.1.50 | 5alpha-dihydroprogesterone + 2 NADPH + 2 H+ |
in the prostate: forward reaction by type 2 isozyme AKR1C3, reverse reaction by type 3 isozyme AKR1C2 |
| 1.1.1.50 | 5alpha-dihydroprogesterone + 2 NADPH + 2 H+ |
inactivation of the potent androgen, 3alpha(beta)-hydroxysteroid oxidoreductase activity |
| 1.1.1.50 | 5alpha-dihydroprogesterone + 2 NADPH + 2 H+ |
isozyme AKR1C4 |
