EC Number |
Natural Substrates |
---|
1.1.1.88 | (R)-mevalonate + CoA + 2 NAD+ |
- |
1.1.1.88 | (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ |
- |
1.1.1.88 | (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ |
mevalonate is required for cholesterol and isoprenoid synthesis |
1.1.1.88 | (S)-3-hydroxy-3-methylglutaryl-CoA + NADH + H+ |
mevalonate is first commited intermediate in polyisoprenoid synthesis |
1.1.1.88 | 3-hydroxy-3-methyl-glutaryl-CoA + NADH + H+ |
mevalonate pathway |
1.1.1.88 | 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ |
- |
1.1.1.88 | 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+ |
the enzyme is highly specific for NADH |
1.1.1.88 | more |
The biosynthetic pathway leading to plant cytosolic isoprenoids begins with the 3-hydroxy-3-methyl-glutaryl CoA reductase-mediated production of mevalonate |
1.1.1.88 | more |
The enzyme can play a role in indole alkaloid biosynthesis and a possible cosuppression of both the endogenous and foreign enzyme genes in clone 236 |