EC Number |
Natural Substrates |
---|
1.14.11.11 | (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
- |
1.14.11.11 | (6S)-6-hydroxyhyoscyamine + 2-oxoglutarate + O2 |
key enzyme in the biosynthesis pathway of scopolamine |
1.14.11.11 | L-hyoscyamine + 2-oxoglutarate + O2 |
- |
1.14.11.11 | L-hyoscyamine + 2-oxoglutarate + O2 |
the enzyme catalyzes two consecutive oxidation reactions leading from hyoscyamine to scopolamine |
1.14.11.11 | L-hyoscyamine + 2-oxoglutarate + O2 |
enzyme is involved in biosynthetic pathway leading to scopolamine |
1.14.11.11 | L-hyoscyamine + 2-oxoglutarate + O2 |
key enzyme in the biosynthesis pathway of scopolamine |
1.14.11.11 | L-hyoscyamine + 2-oxoglutarate + O2 |
the enzyme catalyzes the hydroxylation of (-)-hyoscyamine and the subsequent epoxidation of 6beta-hydroxyhyoscyamine to form scopolamine, a natural alkaloid |
1.14.11.11 | more |
methyl jasmonate and salicylic acid increase the expression of the enzyme |
1.14.11.11 | more |
hyoscyamine 6beta-hydroxylase, a 2-oxoglutarate-dependent dioxygenase, converts L-hyoscyamine to its 6,7-epoxy derivative, scopolamine, in two sequential steps. 6,7-Dehydrohyoscyamine, a potential precursor for the last step of epoxidation, is an obligatory intermediate in the biosynthesis of scopolamine |