EC Number |
Natural Substrates |
---|
1.3.1.2 | 5,6-dihydrouracil + NADP+ |
- |
1.3.1.2 | 5,6-dihydrouracil + NADP+ |
first and rate-limiting enzyme in the three-step pathway for the degradation of uracil |
1.3.1.2 | 5-fluorouracil + NADPH + H+ |
- |
1.3.1.2 | dihydrofluorouracil + NADP+ |
- |
1.3.1.2 | dihydrofluorouracil + NADP+ |
dihydrofluorouracil is further metabolized to 2'-fluoro-beta-alanine |
1.3.1.2 | dihydrothymine + NADP+ |
- |
1.3.1.2 | dihydrouracil + NADP+ |
- |
1.3.1.2 | thymine + NADPH |
- |
1.3.1.2 | thymine + NADPH |
rate-limiting enzyme in catabolic detoxification of exogenous fluoropyrimidines |
1.3.1.2 | thymine + NADPH |
rate-limiting enzyme of thymidine and uridine degradation |