EC Number   |
Natural Substrates |
|---|
   1.5.1.15 | 5,10-methenyltetrahydrofolate + NADH + H+ |
- |
| 1.5.1.15 | 5,10-methylenetetrahydrofolate + NAD+ |
- |
| 1.5.1.15 | 5,10-methylenetetrahydrofolate + NAD+ |
enzyme provides one-carbon units for purine synthesis during embryogenesis, metabolism overview |
| 1.5.1.15 | 5,10-methylenetetrahydrofolate + NADP+ |
- |
| 1.5.1.15 | L-5,10-methenyl-tetrahydrofolate + NADH |
- |
| 1.5.1.15 | L-5,10-methenyl-tetrahydrofolate + NADH |
physiological direction in most organisms is the forward rection, in the acetogens the reverse reaction is the physiologically important one |
| 1.5.1.15 | L-5,10-methylenetetrahydrofolate + NAD+ |
- |
| 1.5.1.15 | more |
enzyme deficiency results in a number of diseases |
| 1.5.1.15 | more |
key enzyme in folate metabolism playing a major role in provision of methyl groups for DNA methylation and in production of dTMP for DNA synthesis |
| 1.5.1.15 | more |
MTHFD2 interacts with mitochondrial ETC complex III in mitochondria, mechanism |
