EC Number   |
Natural Substrates |
|---|
  1.8.4.11 | calmodulin L-methionine-(S)-sulfoxide + thioredoxin |
MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues, which restores the calmodulin binding to adenylate cyclase of the pathogen Bordetella pertussis, which is an essential step for the bacterium to enter host cells, overview |
| 1.8.4.11 | calmodulin-L-methionine (S)-sulfoxide + thioredoxin |
- |
| 1.8.4.11 | dabsyl-L-methionine (S)-sulfoxide + thioredoxin |
- |
| 1.8.4.11 | Hsp21 L-methionine S-oxide + dithiothreitol |
chloroplast-localized small heat shock protein, repair function for heat shock protein Hsp21 by restoring the structure, which is crucial for cellular resistance to oxidative stress, the enzyme can protect the chaperone-like activity of Hsp21 |
| 1.8.4.11 | L-methionine (R,S)-sulfoxide + thioredoxin |
the enzyme protects cells against oxidative damage and plays a role in age-related misfunctions |
| 1.8.4.11 | L-methionine (S)-sulfoxide + 2 dithiothreitol |
- |
| 1.8.4.11 | L-methionine (S)-sulfoxide + dithiothreitol |
the myristoylated enzyme form reduces methionine sulfoxide in protein much faster than the nonmyristoylated form |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin |
- |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin |
enzyme is involved in repairing of oxidized methionine residues in proteins |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin |
FMsr is absolutely specific for the S-isomer of free methionine sulfoxide, no activity with protein bound methionine sulfoxide |
