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Results 1 - 5 of 5
EC Number Natural Substrates Commentary (Nat. Sub.)
Display the reaction diagram Show all sequences 1.8.5.8hydrogen sulfide + glutathione + a quinone -
Display the reaction diagram Show all sequences 1.8.5.8hydrogen sulfide + glutathione + coenzyme Q -
Display the reaction diagram Show all sequences 1.8.5.8hydrogen sulfide + glutathione + quinone -
Display the reaction diagram Show all sequences 1.8.5.8hydrogen sulfide + glutathione + ubiquinone -
Display the reaction diagram Show all sequences 1.8.5.8more under physiological conditions, the primary sulfane sulfur acceptor for the SQOR reaction is GSH, generating glutathione persulfide (GSSH) as the product. Substrate promiscuity leads to dead-end complexes. Human SQOR exhibits remarkable substrate promiscuity, and in addition to sulfide, a number of nucleophiles can add to the resting trisulfide. The addition of alternative nucleophiles to resting SQOR leads to the corresponding 379Cys mixed disulfide and the 201Cys-SS- persulfide that forms an intense charge transfer (CT) complex with FAD. Unlike the sulfide-induced CT complex, which decays quickly to yield FADH2, the alternative CT complexes represent dead-end complexes and decay slowly at rates that approximate the respective dissociation rate constants (koff) for the nucleophiles. Although these dead-end complexes could entrap SQOR in an unproductive state, their formation is suppressed to some extent by the membrane environment of SQOR
Results 1 - 5 of 5