EC Number   |
Natural Substrates |
|---|
   4.2.99.18 | AP DNA |
AP sites |
| 4.2.99.18 | AP-DNA |
- |
| 4.2.99.18 | AP-DNA |
Base excision repair pathway, enzyme cleaves the 5'-phosphodiester bond, generating 3'-OH and 5'-dRP termini |
| 4.2.99.18 | DNA |
- |
| 4.2.99.18 | DNA |
base excision repair (BERa) pathway is initiated by lesion-specific glycosylases that excise the damaged base from the sugar-phosphate backbone, resulting in a potentially cytotoxic apurinic/apyrimidinic (AP) site intermediate that becomes the substrate for the major human AP endonuclease |
| 4.2.99.18 | DNA |
bifunctional enzyme is involved in base excision repair, it is a bifunctional DNA glycosylase/apurinic/apyrimidinic lyase which removes hydrated, reduced, or oxidized bases from the DNA backbone as the initial step of base excision repair |
| 4.2.99.18 | DNA |
DNA repair enzyme is involved in base excision repair of apurinic/apyrimidinic sites after oxidative DNA damage |
| 4.2.99.18 | DNA |
DNA single-strand breaks containing 3'-blocking groups are generated from attack of the sugar backbone by reactive oxygen species or after base excision by DNA glycosylase, apurinic, apyrimidinic (AP) lyases |
| 4.2.99.18 | DNA |
DNA single-strand breaks containing 3'-blocking groups are generated from attack of the sugar backbone by reactive oxygen species or after base excision by DNA glycosylase/apurinic/apyrimidinic (AP) lyases |
| 4.2.99.18 | DNA |
enzyme plays an important role in oxidative signalling, transcription factor regulation, and cell cycle control |
