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EC Number Recommended Name Application Commentary
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.117(4-O-methyl)-D-glucuronate---lignin esterase more fungal glucuronoyl esterases (FGEs) catalyze cleavage of the ester bond connecting a lignin alcohol to the xylan-bound 4-O-methyl-D-glucuronic acid of glucuronoxylans. Thus, FGEs are capable of degrading lignin-carbohydrate complexes and have potential for biotechnological applications toward woody biomass utilization
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.117(4-O-methyl)-D-glucuronate---lignin esterase more glucuronoyl esterases are highly important enzymes for industrial applications that aim for selective lignin recovery in order to obtain a final high-quality lignin product from hardwood
Display the word mapDisplay the reaction diagram Show all sequences 3.8.1.9(R)-2-haloacid dehalogenase more D-specific dehalogenase DehD from Rhizobium sp. strain RC1 can be exploited as a potential target enzyme for industrial, pharmaceutical and other biotechnological applications
Show all pathways known for 3.8.1.2Display the word mapDisplay the reaction diagram Show all sequences 3.8.1.2(S)-2-haloacid dehalogenase more L-2-haloacid dehalogenase acts specifically on L-2-haloalkanoic acids to produce D-2-hydroxyalkanoic acids, which have potential applications in chemical industries and bioremediation
Show all pathways known for 3.8.1.2Display the word mapDisplay the reaction diagram Show all sequences 3.8.1.2(S)-2-haloacid dehalogenase more the L-haloacid dehalogenase from a psychrotrophic Pseudoalteromonas from the Arctic revealed its potential in industrial applications such as in synthetic chemistry and environmental protection
Display the reaction diagram Show all sequences 2.1.1.122(S)-tetrahydroprotoberberine N-methyltransferase more low TNMT activity
Show all pathways known for 1.1.1.267Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.2671-deoxy-D-xylulose-5-phosphate reductoisomerase more the enzyme is a target for development of antibacterial drugs, determination of the antimicrobial activities of various essential oils against different microbials
Display the word mapDisplay the reaction diagram Show all sequences 3.13.1.32'-hydroxybiphenyl-2-sulfinate desulfinase more environmental protection, the enzyme is useful in biodesulfurization, in which microorganisms selectively remove sulfur atoms from organosulfur compounds, a viable technology to complement the traditional hydrodesulfurization of fuels
Display the word mapDisplay the reaction diagram Show all sequences 2.7.1.1602'-phosphotransferase more Inhibitors of Tpt1p might prove useful as selective antifungal agents.
Show all pathways known for 2.3.1.117Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.1172,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase more DapA is not an optimal target for drug development against Pseudomonas aeruginosa
Display the word mapDisplay the reaction diagram Show all sequences 3.7.1.242,4-diacetylphloroglucinol hydrolase more by degrading 2,4-diacetylphloroglucinol to mildly toxic monoacetylphloroglucinol, PhlG may help avoid accumulation of a metabolite that at high levels may become toxic to the producing bacterium, as has been observed for strains CHA0 and F11
Show all pathways known for 1.2.1.26Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.262,5-dioxovalerate dehydrogenase more the ALDH branch including ycbD protein is designated the KGSADH subclass (type III)
Show all pathways known for 1.2.1.26Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.262,5-dioxovalerate dehydrogenase more three different types of KGSADH appear in the bacterial evolutional stage convergently
Show all pathways known for 1.2.1.105Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.1052-oxoglutarate dehydrogenase system more alpha-ketoglutarate-involving reactions belong to the backbone of high-flux reactions, which is rather conserved in evolution
Show all pathways known for 1.2.1.105Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.1052-oxoglutarate dehydrogenase system more in post-mortem mice brain samples the activity is quickly lost, whereas the activity of another TPP-dependent enzyme, PDH, remains unalterd for at least 24 h
Show all pathways known for 2.1.1.116Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1163'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase more localization of seven biosynthetic enzymes to the sieve elements, unique, cell type-specific biosynthesis of benzylisoquinoline alkaloids in the opium poppy
Show all pathways known for 2.1.1.116Display the word mapDisplay the reaction diagram Show all sequences 2.1.1.1163'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase more the fragment A11A1 with increased expression in Papaver somniferum plants compared to other Papaver species shows the highest homology (75% identity on protein level) to the 4'-OMT from Coptis japonica
Show all pathways known for 1.1.1.31Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.313-hydroxyisobutyrate dehydrogenase more 3-HIBADH may play a role in biosynthesis of 3-hydroxypropionate as a biological source
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.43-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) more activation of the translational regulators by leucine is partly regulated by the activity of BCKDH complex
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.43-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) more NMR techniques to determine the structure of hbSBD and dynamics of several truncated constructs from the E2 component, including hbLBD (residues 1–84), hbSBD (residues 111–149), and a di-domain (hbDD) (residues 1–166) comprising hbLBD, hbSBD and the interdomain linker, the presence of the interdomain linker restricts the motional freedom of the hbSBD more significantly than hbLBD, the linker region likely exists as a soft rod rather than a flexible string in solution
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.43-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) more regulation of BCKD kinase expression by nutritional, hormonal, and pathological factors
Display the word mapDisplay the reaction diagram Show all sequences 1.2.4.43-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) more use of a microRNA to exert control on a metabolic pathway of amino acid catabolism
Show all pathways known for 1.3.1.22Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.223-oxo-5alpha-steroid 4-dehydrogenase (NADP+) more two isoenzymes of 5alphaR is probably characteristic of the whole plant kingdom
Show all pathways known for 1.3.99.4Display the word mapDisplay the reaction diagram Show all sequences 1.3.99.43-oxosteroid 1-dehydrogenase more ksdD-1 and ksdD-2 display respectively high (78%) and low (33%) amino acid sequence identity with the putative ksdD gene of Mycobacterium tuberculosis
Show all pathways known for 1.3.99.4Display the word mapDisplay the reaction diagram Show all sequences 1.3.99.43-oxosteroid 1-dehydrogenase more the two putative Mycobacterium tuberculosis KsdDs, MT3641 and MT0809, complement the Mycobacterium smegmatis deltaksdD-1 deltaksdD-2 double mutant
Show all pathways known for 1.3.99.4Display the word mapDisplay the reaction diagram Show all sequences 1.3.99.43-oxosteroid 1-dehydrogenase more 3-oxosteroid DELAT1-dehydrogenases are of particular interest for the etiology of some infectious diseases, for the production of starting materials for the pharmaceutical industry, and for environmental bioremediation applications
Show all pathways known for 3.1.3.8Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.83-phytase more PhyA115 is a beta-propeller phytase that has application potential in aquaculture feed
Show all pathways known for 3.1.3.8Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.83-phytase more phytase has great potential applications not only in the areas of animal nutrition and resource conservation, but also in environmental protection and public health
Show all pathways known for 3.1.3.8Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.83-phytase more phytases show great potential for application in different sectors such as in animal nutrition, human nutrition, aquaculture, and pharmacology. These enzymes are considered as a green feed additive that can be used to neutralize the antinutritional effects of phytate, thereby increasing the bioavailability of phosphorus and other minerals. They also contribute to the reduction of environmental pollution by phosphorus
Show all pathways known for 3.1.3.8Display the word mapDisplay the reaction diagram Show all sequences 3.1.3.83-phytase more the enzyme is useful as animal feed additive, in dephytinization of food ingredients, and bioremediation of phosphorous pollution in the environment
Show all pathways known for 3.2.1.141Display the word mapDisplay the reaction diagram Show all sequences 3.2.1.1414-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase more trehalose is gaining applications as sweetener component, preservative or stabilizer of food, cosmetics, vaccines, medicines, cells, and organs
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.344-dimethylallyltryptophan synthase more prenyltransferases of the dimethylallyl-tryptophan synthase superfamily catalyze Friedel-Crafts alkylation with high flexibility for aromatic substrates, but the high specificity for dimethylallyl diphosphate prohibits their application as biocatalysts
Show all pathways known for 4.3.3.7Display the word mapDisplay the reaction diagram Show all sequences 4.3.3.74-hydroxy-tetrahydrodipicolinate synthase more the enzyme is not an optimal target for drug development against Pseudomonas aeruginosa
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.844-hydroxyacetophenone monooxygenase more as acylcatechols are valuable synthons for the fine chemical industry, HAPMO might develop as a useful biocatalytic tool
Display the word mapDisplay the reaction diagram Show all sequences 1.14.13.844-hydroxyacetophenone monooxygenase more potential of HAPMO for biotechnological applications
Show all pathways known for 1.1.7.1Display the word mapDisplay the reaction diagram Show all sequences 1.1.7.14-hydroxybenzoyl-CoA reductase more contains three open reading frames coding for proteins with very high similiarities to 4-HBCR from Thauera aromatica with 85%, 70% and 91% identities respectively
Display the reaction diagram Show all sequences 1.2.1.614-hydroxymuconic-semialdehyde dehydrogenase more HapE shows 45% sequence identity with CymC, a p-cumic aldehyde dehydrogenase, from Pseudomonas putida
Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.B315-dimethylallyltryptophan synthase more prenyltransferases of the dimethylallyl-tryptophan synthase superfamily catalyze Friedel-Crafts alkylation with high flexibility for aromatic substrates, but the high specificity for dimethylallyl diphosphate prohibits their application as biocatalysts
Show all pathways known for 1.5.1.34Display the word mapDisplay the reaction diagram Show all sequences 1.5.1.346,7-dihydropteridine reductase more the purified recombinant enzyme from Escherichia coli is used for 5,6,7,8-tetrahydropteridine (BH4) regeneration to alleviate 7,8-dihydropteridine (BH2) inhibition of L-tyrosine hydroxylation by crude tyrosine hydroxylase (SrTH) from Streptosporangium roseum DSM 43021 as part of a combined whole-cell catalyst, and a series of tyrosine hydroxylase/sepiapterin reductase (TH/SPR) synthesis systems, overview
Show all pathways known for 2.5.1.78Display the word mapDisplay the reaction diagram Show all sequences 2.5.1.786,7-dimethyl-8-ribityllumazine synthase more protection of mice against Shiga toxin 2 (Stx2)-associated damage by maternal immunization with a Brucella lumazine synthase-Stx2 B subunit chimera. The enzyme can be useful in vaccine development against enterohemorrhagic Shiga toxin (Stx)-producing Escherichia coli (EHEC), which causes a prodromal hemorrhagic enteritis, remaining the most common etiology of the typical or epidemic form of hemolytic-uremic syndrome. The EHEC challenge contributes to sustain a specific and protective immune response against Stx2
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.3248-hydroxygeraniol dehydrogenase more plant (4aR,7S,7aS)-nepetalactone can be used for synthesis of (4aR,7S,7aS)-nepetalactol, an aphid pheromone, useful in aphid control
Display the word mapDisplay the reaction diagram Show all sequences 7.3.2.5ABC-type molybdate transporter more specifically binds MoO42-/WO42- but not SO42-, mainly because the desolvation penalty of MoO42-/WO42- is significantly less than that of SO42- and, to a lesser extent, because the large and rigid cavity in these proteins attenuates ligand interactions with SO42-, as compared to MoO42-, exclusion of positively charged Lys/Arg side chains in the anion-binding sites of ModA, because Lys/Arg do not contribute to the selectivity of the binding pocket and substantially stabilize the complex between the oxyanion and protein ligands, which in turn would prohibit the rapid release of the bound oxyanion at a certain stage during the transport process
Display the word mapDisplay the reaction diagram Show all sequences 7.3.2.5ABC-type molybdate transporter more transcription of modABC genes is repressed by molybdate
Display the word mapDisplay the reaction diagram Show all sequences 7.4.2.2ABC-type nonpolar-amino-acid transporter more N-I permease is necessary for normal growth of Anabaena sp. on N2, plays a role in the diazotrophic filament specifically in vegetative cells, the products of Anabaena open reading frames all1046, all1047, all1284, alr1834 and all2912 are putative elements of the neutral amino acid permease
Display the word mapDisplay the reaction diagram Show all sequences 7.4.2.2ABC-type nonpolar-amino-acid transporter more the aromatic and neutral aliphatic amino acid permease PcMtr is unrelated to the amino acid permease family, which includes most amino acid permeases in fungi
Display the word mapDisplay the reaction diagram Show all sequences 7.4.2.1ABC-type polar-amino-acid transporter more BcaP is required for optimal growth in media containing free amino acids as the sole amino acid source
Display the word mapDisplay the reaction diagram Show all sequences 7.4.2.1ABC-type polar-amino-acid transporter more conformational changes within HisP that are dependent on the presence of ATP in the binding pocket of the protein, changes are predominantely confined to the alpha-helical subdomain, considerable conformational flexibility in a conserved glutamine-containing loop
Display the word mapDisplay the reaction diagram Show all sequences 7.4.2.1ABC-type polar-amino-acid transporter more identification of a GTPase-containing complex for Gap1p sorting in the endosomes, which has a key role in trafficking Gap1p out of the late endosome and may serve as coat proteins in this process, the complex contains the GTPases Gtr1p and Gtr2p, delivery of Gap1p to the plasma membrane depends on specific nucleotide-bound states of the GTPases, Gtr2p interacts with the C-terminal cytosolic domain of Gap1p, a tyrosine-containing motif in this domain is necessary both to bind Gtr2p and to direct sorting of Gap1p to the plasma membrane
Display the word mapDisplay the reaction diagram Show all sequences 7.4.2.1ABC-type polar-amino-acid transporter more role of ubiquitination appears to be a signal for delivery of Gap1p to the multivesicular endosome, whereas amino acid abundance appears to control the cycling of Gap1p from the multivesicular endosome to the plasma membrane, Gap1p recycling does not depend on other known pathways for recycling proteins from the endosome to Golgi compartments
Display the word mapDisplay the reaction diagram Show all sequences 7.4.2.1ABC-type polar-amino-acid transporter more the aromatic and neutral aliphatic amino acid permease PcMtr is unrelated to the amino acid permease family, which includes most amino acid permeases in fungi
Display the word mapDisplay the reaction diagram Show all sequences 7.4.2.1ABC-type polar-amino-acid transporter more UfAAT3 encodes a protein with a high degree of sequence similarity to fungal amino acid permeases
Display the word mapDisplay the reaction diagram Show all sequences 7.4.2.1ABC-type polar-amino-acid transporter more VfAAP1 expression increases seed sink strength for nitrogen, improves plant nitrogen status, and leads to higher seed protein
Display the word mapDisplay the reaction diagram Show all sequences 7.6.2.9ABC-type quaternary amine transporter more betaine and carnitine transport upon low temperature exposure is mediated via three osmolyte transporters including OpuC, carnitine uptake for cryoprotective purposes, OpuB shows no significant contribution to listeral chill tolerance
Display the word mapDisplay the reaction diagram Show all sequences 7.6.2.9ABC-type quaternary amine transporter more functional re-association of a substrate-binding protein-dependent ABC-transporter starting from the isolated subunits
Display the word mapDisplay the reaction diagram Show all sequences 7.6.2.9ABC-type quaternary amine transporter more Na+-betaine symporter that contributes to the salt stress tolerance at alkaline pH
Display the word mapDisplay the reaction diagram Show all sequences 7.6.2.9ABC-type quaternary amine transporter more osmotic control of the OpuA operon allows the cell to sensitively adjust the number of the OpuA transporter to the physiological need of the cell
Display the word mapDisplay the reaction diagram Show all sequences 7.6.2.9ABC-type quaternary amine transporter more the cystathionine beta-synthase module in OpuA constitutes the ionic strength sensor whose activity is modulated by the C-terminal anionic tail
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.7acetylcholinesterase more use of enzyme as a molecular marker of the nervous system in platyhelminthes
Display the word mapDisplay the reaction diagram Show all sequences 3.1.1.7acetylcholinesterase more AChE from the juvenile Colossoma macropomum brain can be used as an alternative biocomponent of organophosphorus and carbamate biosensors in routine pesticide screening in the environment
Display the reaction diagram Show all sequences 3.7.1.6acetylpyruvate hydrolase more 75fold increased productivity of the enzyme by media optimization, optimal glucose, yeast extract and (NH4)2SO4 concentrations produce 7fold more biomass than the initial medium, optimization also by determining the optimal time of feed and amount of orcinol
Show all pathways known for 1.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 1.3.3.6acyl-CoA oxidase more ACOX1 alternative splicing isoforms play a key conserved role in the vertebrate fatty acid metabolism, tissue-specific modulation of ACOX1 activity by exchanging exon 3 duplicated isoforms containing amino acid sequences that are potentially implicated in fatty acyl chain specificity
Show all pathways known for 1.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 1.3.3.6acyl-CoA oxidase more inability of ACX1, ACX3, and ACX4 to fully compensate for one another in indole-3-butyric acid-mediated root elongation inhibition and ability of ACX2 and ACX5 to contribute to indole-3-butyric acid response suggests that indole-3-butyric acid-response defects in acx mutants may reflect indirect blocks in peroxisomal metabolism and indole-3-butyric acid beta-oxidation, rather than direct enzymatic activity of ACX isozymes on indole-3-butyric acid-CoA
Show all pathways known for 1.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 1.3.3.6acyl-CoA oxidase more isomerase activity of rat peroxisomal acyl-CoA oxidase I, is probably due to a spontaneous process driven by thermodynamic equilibrium with formation of a conjugated structure after deprotonation of substrate alpha-proton
Show all pathways known for 1.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 1.3.3.6acyl-CoA oxidase more nervonic acid is discharged from the spore into the external medium during firing along with the catalase and ACOX enzymes
Show all pathways known for 1.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 1.3.3.6acyl-CoA oxidase more novel Pex5pM is functional and a seven amino acids-insertion, which is present in the L isoform but absent in the M isoform, plays some role in the process of maturation of Aox
Show all pathways known for 1.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 1.3.3.6acyl-CoA oxidase more solvent-accessible acyl binding pocket is not required for oxygen reactivity, the oligomeric state plays a role in substrate pocket architecture but is not linked to oxygen reactivity
Show all pathways known for 1.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 1.3.3.6acyl-CoA oxidase more three distinct ACX genes, ACX1 is upregulated by wounding, both locally and systemically, ACX1 may play a role in the synthesis of jasmonic acid in response to wounding
Show all pathways known for 1.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 1.3.3.6acyl-CoA oxidase more three distinct ACX genes, expression of ACX2 remains unchanged by wounding, ACX2 may be involved in providing germinating seeds with sugar and energy
Show all pathways known for 1.3.3.6Display the word mapDisplay the reaction diagram Show all sequences 1.3.3.6acyl-CoA oxidase more three distinct ACX genes, expression of ACX3 remains unchanged by wounding
Display the word mapDisplay the reaction diagram Show all sequences 3.5.1.97acyl-homoserine-lactone acylase more fundamental roles in biofilm formation
Display the word mapDisplay the reaction diagram Show all sequences 3.4.19.1acylaminoacyl-peptidase more amino acid sequence of PMH displays high similarity to that of the Streptomyces acyl-peptide hydrolase. PMH is an aminopeptidase carrying a putative catalytic triad, Ser511-Asp593-His625, with broad substrate specificity
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.82ADAMTS-4 endopeptidase more neurite extension mediated by the MAP kinase pathway, increased number of primary and secondary neurites
Display the word mapDisplay the reaction diagram Show all sequences 3.4.24.B12ADAMTS5 endopeptidase more neurite extension mediated by the MAP kinase pathway, increased number of primary and secondary neurites
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more 15 putative AC genes present
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more AC8 acts as a low-pass filter for high-frequency Ca2+ events, enhancing the regulatory options available to this signalling pathway
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more ACA has the same architecture as mammalian membrane-bound ACs, is essential for reacting to and production of cAMP. ACG is essential for germination. ACB is required for terminal maturation of spores
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more ACIII is a marker for primary cilia throughout many regions of the adult mouse brain
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more ACT enhances the adhesive functions of filamentous haemagglutinin and modifies the performance of the filamentous haemagglutinin heparin-inhibitable carbohydrate binding site
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more activation of the HCO3-/sAC transduction pathway enhances both cftr gene and CFTR protein expression and appears to be a physiological mechanism whereby the cell adapts to variations in extracellular HCO3- concentration
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more both sAC and tmACs participate in the sperm acrosome reaction and sperm motility
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more Ca2+-stimulated AC regulates If via cAMP, modulation of the If pacemaker current
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more can function as a ion channel
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more class IV AC fold is distinct from the previously described folds for class II and class III ACs
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more compartmentalization of cAMP signalling, cAMP levels change in discrete domains of the cell with discrete local consequences
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more contains a GGDEF domain
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more CyaB1 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more CyaB2 is composed of two GAF domains, a PAS domain, a CHD and a single tetratricopeptide repeat
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more CyaC consists of a receiver domain, two GAF domains, a histidine kinase domain, another receiver and a CHD
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more endothelin-1 deficiency increases inner medullary collecting duct AC5/6 content, that may synergize with acute endothelin-1 inhibition of vasopressin-stimulated cAMP accumulation
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more essential role of Ca2+/calmodulin-regulated ACs in learning and memory
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more interaction between the N-terminus of AC5 and the guanine nucleotide exchange factor Ric8a provides a pathway to fine-tune AC5 activity via a Galphai mediated pathway
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more involved in sensing high osmotic pressure
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more is an exotoxin
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more isoform-selective signaling complexes likely contribute to various functional consequences of cAMP elevation in vascular smooth muscle cells. AC1 isoform contributes to modulation of extracellular signal-regulated kinase signaling, proliferation, and control of cell division, whereas AC6, at least partly because of uncoupling of cAMP synthesis from cAMP breakdown, results in sustained cAMP accumulation, vasodilator-stimulated phosphoprotein phosphorylation, and control of cytoskeletal rearrangements that contribute to vascular arborization
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more membrane transitions in cAMP strengthen the endothelial cell barrier, whereas the production of cAMP by soluble AC within the cytosol away from the membrane disrupts the endothelial cell barrier
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more overexpression of AC1 in forebrain enhances long-term potentiation
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more restores adenylate cyclase activity in Escherichia coli knockout mutants
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more Rv0386 shows both adenylyl and a guanylyl cyclase side-activity
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more Rv1120c is a pseudogene in Mycobacterium tuberculosis
Show all pathways known for 4.6.1.1Display the word mapDisplay the reaction diagram Show all sequences 4.6.1.1adenylate cyclase more Rv1264 plays a role in mycobacterial survival in the acidic environment of the pahgolysosome
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