EC Number |
Application |
Reference |
---|
1.13.11.27 | agriculture |
4-hydroxyphenylpyruvate dioxygenase is one of the most promising target sites for herbicide discovery |
743407 |
1.13.11.27 | agriculture |
4-hydroxyphenylpyruvate dioxygenase modified at position 336 (HPPD W336) is expressed in MST-FGO72-2 soybean to confer tolerance to 4-benzoyl isoxazole and triketone type of herbicides. No relevant sequence homologies are found with known allergens or toxins, and the absence of hemolytic activity of HPPD W336 is demonstrated in vitro. HPPD W336 degrades rapidly in simulated gastric fluid. Expression of HPPD W336 does not change aromatic amino acid, homogentisate and tocochromanol levels in soybean seed |
-, 765752 |
1.13.11.27 | agriculture |
analysis of two waterhemp populations resistant to p-hydroxyphenylpyruvate-dioxygenase herbicides shows that the HPPD-resistance trait is polygenic. The number of genes involved with the herbicide resistance increase at higher herbicide rates, indicating at least one dominant allele at each major locus is required to confer HPPD herbicide resistance in waterhemp |
765613 |
1.13.11.27 | agriculture |
overexpression of enzyme in Nicotiana tabacum, transgenic plants have a 10-fold higher resistance to the bleaching herbicide sulcotrione, transgenic seeds have an up to two-fold enhanced level of vitamin E without change in the ratio of gamma-tocopherol and gamma-tocotrienol. Level of plastoquinone is enhanced in leaves of transgenic lines during leaf senescence |
658710 |
1.13.11.27 | agriculture |
plant 4-hydroxyphenylpyruvate dioxygenase (HPPD) is the molecular target of a range of commercial synthetic beta-triketone herbicides Their mode of action is based on an irreversible inhibition of HPPD |
741741 |
1.13.11.27 | agriculture |
the enzyme is a target for herbicides, e.g. triketone inhibitors |
741762 |
1.13.11.27 | analysis |
colorimetric bacterial whole-cell screening system based on the degradation of tyrosine through 4-hydroxyphenylpyruvate into homogentisate by human HPD expressed in Escherichia coli and subsequent production of a soluble melanin-like pigment. The addition of prototypical beta-triketone HPD inhibitors decreases pigment production in a dose-dependent manner with increasing inhibitor concentrations. The high-throughput screening assay shows plate uniformity, signal variability and spatial uniformity assessment |
765822 |
1.13.11.27 | diagnostics |
the enzyme can be used for enzyme-based sensors for monitoring herbicides used in agriculture, i.e. mesotrione. Compared to the standard sensors, biosensors have assorted advantages, such as practicality, quick response, low cost, and high sensitivity. A nanobiosensor is developed based on HPPD for mesotrione detection |
742632 |
1.13.11.27 | drug development |
4-hydroxyphenylpyruvate dioxygenase (HPPD), an essential enzyme in tyrosine catabolism, is an important target for treating type I tyrosinemia |
742451 |
1.13.11.27 | drug development |
4-hydroxyphenylpyruvate dioxygenase is one of the most promising target sites for herbicide discovery |
743407 |