EC Number   |
Application |
Reference |
|---|
    1.2.1.105 | analysis |
sensitive and rapid assay procedures for human mitochondrial the pyruvate dehydrogenase (PDH) complex, the 2-oxoglutarate dehydrogenase (OGDH) complex and their 5 component enzymes, for use with crude tissue extracts |
759549 |
| 1.2.1.105 | medicine |
altered in the post-mortem substantia nigra samples from patients suffering from Parkinson's disease, decreased activity in the brain of Alzheimer's disease patients, involving regions affected by the disease as well as regions that remain normal, reduced activity or increased vulnerability to oxidative stress in fibroblasts from patients with presenlilin-1 mutation |
676319 |
| 1.2.1.105 | medicine |
hypochlorous acid and chloramines have the potential to inactivate KGDHC, a major target in neurodegeneration |
656591 |
| 1.2.1.105 | medicine |
hypochlorous acid and chloramines have the potential to inactivate KGDHC, a major target in neurodegeneration, without significant loss of cellular viability |
656591 |
| 1.2.1.105 | medicine |
key regulatory branch points of mitochondrial metabolism are targets of a cellular derivative of phytanic acid, decreased activity of the complexes may contribute to neurological symptoms upon accumulation of phytanic acid in Refsum disease |
673654 |
| 1.2.1.105 | medicine |
KGDHC is diminished in brains from patients with Alzheimers's disease, Parkinson's disease, Huntington's disease, Wernicke-Korskoff disease, and progressive supranuclear palsy, not diminished in brains of patients that died with schizophrenia, reduced KDGDHC may be a better indicator of the primary reactive oxygen species action than commonly used measures of oxidative stress |
676088 |
| 1.2.1.105 | medicine |
loss of KGDHC activity resulting from the lack of thiamine diphosphate coenzyme may lead to oxidative stress and to neuronal death both directly and by predisposing to other insults |
676088 |
| 1.2.1.105 | medicine |
plays a role in neurodegenerative diseases |
676319 |
| 1.2.1.105 | medicine |
potential of succinyl phosphonate esters for modeling the biochemical and pathophysiological consequences of reduced KGDHC activity in brain diseases |
675552 |
| 1.2.1.105 | medicine |
succinyl phosphonate and its esters may be useful in studying the effects of reduced KGDHC activity on neuronal and brain function |
671961 |
