cyclopentanone + NADPH + H+ + O2 = 5-valerolactone + NADP+ + H2O
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cyclopentanone + NADPH + H+ + O2 = 5-valerolactone + NADP+ + H2O
reaction mechanism via key intermediate flavin C4a-peroxide, involving the four-electron reduction of O2 at the expense of a two-electron oxidation of NADPH and a two-electron oxidation of cyclohexanone to epsilon-caprolactone, overview
cyclopentanone + NADPH + H+ + O2 = 5-valerolactone + NADP+ + H2O
residues Phe450 and Phe156 are important for reaction stereospecificity
cyclopentanone + NADPH + H+ + O2 = 5-valerolactone + NADP+ + H2O
the reaction mechanism of BVMO with native substrate phenylacetone proceeds via the formation of a Criegee intermediate with anionic character, which is subsequently rearranged via the migration of alkyl group to yield the product ester, reaction mechanism, overview
