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Results 1 - 10 of 10
EC Number
Reaction
Commentary
Reference
a 14alpha-formylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a DELTA14-steroid + formate + [oxidized NADPH-hemoprotein reductase] + H2O
(1c)
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a 14alpha-hydroxymethylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a 14alpha-formylsteroid + [oxidized NADPH-hemoprotein reductase] + 2 H2O
(1b)
-
a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
active site structure, structure-function relationship
a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
heme iron reduction as a rate-limiting step
a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
mechanism
a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
mechanism; stoichiometry
a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
reaction mechanism, phyla-specific residues in CYP51
a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
regulation
a 14alpha-methylsteroid + 3 [reduced NADPH-hemoprotein reductase] + 3 O2 = a DELTA14-steroid + formate + 3 [oxidized NADPH-hemoprotein reductase] + 4 H2O
The heme-thiolate enzyme, P-450, catalyses successive hydroxylations of the 14alpha-methyl group and C-15, followed by elimination as formate leaving the 14(15) double bond. This enzyme acts on a range of steroids with a 14alpha-methyl group
-
a 14alpha-methylsteroid + [reduced NADPH-hemoprotein reductase] + O2 = a 14alpha-hydroxymethylsteroid + [oxidized NADPH-hemoprotein reductase] + H2O
(1a)
-
Results 1 - 10 of 10