EC Number   |
Reaction |
Reference |
|---|
   1.3.3.11 | 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O |
- |
- |
| 1.3.3.11 | 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O |
PqqC is part of a complex of six enzymes that act together in pyrroloquinoline-quinone synthesis: PqqA serves as a complex precursor for for pyrroloquinoline-quinone synthesis, PqqB is not directly required for pyrroloquinoline-quinone biosynthesis, but a carrier and responsible for its transport across the plasma-membrane into the periplasm, PqqC does not contain a redox-active metal or other cofactor and is responsible for the last cyclization and oxidation steps in pyrroloquinoline-quinone synthesis, PqqD has three possible functions: first, it could play a role in the release of pyrroloquinoline-quinone from PqqC, second it could be involved in binding of PqqB to PqqC, third it could function as the dioxygenase in the pathway, PqqE is a family member of radical S-adenosylmethionine enzymes and catalyzes a radical driven C-C bond formation required to link the glutamate and tyrosine moieties at atoms C9 and C9a of pyrroloquinoline-quinone, PqqF recognizes and cleaves all four peptide bonds in PqqA |
685807 |
| 1.3.3.11 | 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O |
PqqC is part of a complex of six enzymes that act together in pyrroloquinoline-quinone synthesis: PqqA serves as a complex precursor for for pyrroloquinoline-quinone synthesis, PqqB is not directly required for pyrroloquinoline-quinone biosynthesis, but a carrier and responsible for its transport across the plasma-membrane into the periplasm, PqqC does not contain a redox-active metal or other cofactor and is responsible for the the last cyclization and oxidation steps in pyrroloquinoline-quinone synthesis, PqqD has three possible functions: first, it could play a role in the release of pyrroloquinoline-quinone from PqqC, second it could be involved in binding of PqqB to PqqC, third it could function as the dioxygenase in the pathway, PqqE is a family member of radical S-adenosylmethionine enzymes and catalyzes a radical driven C-C bond formation required to link the glutamate and tyrosine moieties at atoms C9 and C9a of pyrroloquinoline-quinone, PqqF recognizes and cleaves all four peptide bonds in PqqA |
685807 |
| 1.3.3.11 | 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O |
PqqC is part of a complex of six enzymes that act together in pyrroloquinoline-quinone synthesis: PqqA serves as a complex precursor for for pyrroloquinoline-quinone synthesis, PqqB is not directly required for pyrroloquinoline-quinone biosynthesis, but a carrier and responsible for its transport across the plasma-membrane into the periplasm, PqqC does not contain a redox-active metal or other cofactorand is responsible for the the last cyclization and oxidation steps in pyrroloquinoline-quinone synthesis, PqqD has three possible functions: first, it could play a role in the release of pyrroloquinoline-quinone from PqqC, second it could be involved in binding of PqqB to PqqC, third it could function as the dioxygenase in the pathway, PqqE is a family member of radical S-adenosylmethionine enzymes and catalyzes a radical driven C-C bond formation required to link the glutamate and tyrosine moieties at atoms C9 and C9a of pyrroloquinoline-quinone, PqqF recognizes and cleaves all four peptide bonds in PqqA |
685807 |
| 1.3.3.11 | 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O |
PqqC/D produces the reduced pyrroloquinoline quinone from the intermediate in vivo |
677952 |
| 1.3.3.11 | 6-(2-amino-2-carboxyethyl)-7,8-dioxo-1,2,3,4,7,8-hexahydroquinoline-2,4-dicarboxylate + 3 O2 = 4,5-dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylate + 2 H2O2 + 2 H2O |
reaction mechanism consisting of a series of base catalyzed proton abstractions followed by quinoid/quinol tautomerizations and oxidations, overview |
-, 726458 |
