EC Number   |
Reaction |
Reference |
|---|
   1.1.1.23 | L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+ |
also oxidizes L-histidinal |
656358 |
| 1.1.1.23 | L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+ |
bi uni uni bi ping pong mechanism, recombinant histidinol dehydrogenase |
286324 |
| 1.1.1.23 | L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+ |
bi uni uni bi ping-pong enzyme mechanism for MtHisD-catalyzed chemical reaction, involves abstraction of the hydroxyl group proton of L-histidinol by His336 and concomitant hydride transfer from the reactive carbon (carbon bound to the hydroxyl group that upon hydride transfer adopts the sp2 configuration) to NAD+, forming L-histidinaldehyde and transiently protonated His336 |
-, 721426 |
| 1.1.1.23 | L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+ |
enzyme HisD from Mycobacterium tuberculosis follows a bi uni uni bi ping-pong mechanism in which L-histidinol is the first substrate to bind and L-histidine the last product to dissociate, the amino acid side chains of His336 and Glu335 are likely involved in catalysis and/or substrate binding |
-, 741402 |
| 1.1.1.23 | L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+ |
fast reversible oxidation of L-histidanol, followed by slow irreversible hydride transfer from the intermediate L-histidinal |
286322 |
| 1.1.1.23 | L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+ |
reaction mechanism, amino acid residues Glu326 and His327 are involved in catalysis |
657194 |
| 1.1.1.23 | L-histidinol + 2 NAD+ + H2O = L-histidine + 2 NADH + 2 H+ |
the enzyme catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine using a bi-uni-uni-bi ping pong kinetic mechanism |
-, 741455 |
