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EC Number Reaction Commentary Reference
Show all pathways known for 1.1.1.44Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.446-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+ - -
Show all pathways known for 1.1.1.44Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.446-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+ reductive carboxylation of ribulose-5-phosphate by 6PGDH is investigated using kinetic isotope effects. In the absence of 6-phosphogluconate, a slow step, which precedes the chemical process, is rate-limiting for the reaction, whereas in the presence of 6-phosphogluconate, the rate-limiting step follows the isotope-sensitive step. Full activity of 6PGDH is achieved when one subunit carries out the catalysis and the other subunit carries an unreacted 6-phosphogluconate (allosteric activator) 712444
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