EC Number |
Reaction |
Reference |
---|
1.2.1.105 | 2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH |
- |
- |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 |
2-oxoglutarate dehydrogenase complex consists of 3 enzymes: E1 (alpha-ketoglutarate dehydrogenase, EC 1.2.4.2), E2 (dihydrolipoyl transsuccinylase, EC 2.3.1.61), E3 (dihydrolipoyl dehydrogenase, EC 1.8.1.4) |
348910, 348914, 349001, 349002, 349003, 349004, 349017, 349018, 349019, 349029 |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 |
kinetics of succinylation and desuccinylation |
349022 |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 |
mechanism of the enzyme complex is bi bi uni uni ping pong |
349018 |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 |
mechanism of the reaction catalyzed by the 2-oxoglutarate dehydrogenase complex |
349023 |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 |
substrate channeling and catalytic mechanism, active site coupling |
654557 |
1.2.1.105 | 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 |
the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH |
-, 348910, 348914, 349001, 349002, 349003, 349004, 349005, 349006, 349007, 349008, 349014, 349015, 349017, 349018, 349019, 349020, 349021, 349022, 349023, 349024, 349025, 349026, 349027, 349028, 349029, 349030, 349031, 349032, 349033, 349034, 349035, 349036, 349037, 349038, 349040, 349042, 349043, 349044 |