2.5.1.29 | (2E,6E)-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate |
the condensation of isopentenyl diphosphate to (2E,6E)-farnesyl diphosphate by GGPPS is a bi-substrate/biproduct (bi-bi) reaction, where the two products are geranylgeranyl diphosphate and diphosphate, which is cleaved from (2E,6E)-farnesyl diphosphate. The inhibitory pattern observed by geranylgeranyl diphosphate indicates a compulsory ordered mechanism for isopentenyl diphosphate and (2E,6E)-farnesyl diphosphate binding the enzyme from Choristoneura fumiferana |
738380 |