EC Number |
Reaction |
Reference |
---|
2.5.1.7 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine |
active site SH-group |
637594 |
2.5.1.7 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine |
Asn23 and Asp305 are essential in the active site |
-, 637608 |
2.5.1.7 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine |
Cys115 in the active site can act as proton donor, necessary for activity, or as a nucleophile |
-, 637605 |
2.5.1.7 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine |
Cys115 is the active site nucleophile |
-, 637598, 637599, 637600 |
2.5.1.7 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine |
D305 has a dual role as a general base and an essential binding partner to UDP-GlcNAc |
-, 637608 |
2.5.1.7 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine |
enyme exhibits an open conformation when substrate-free, and a closed, tightly-packed conformation upon substrate binding |
-, 637602, 637608 |
2.5.1.7 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine |
exchange of cysteine to aspartate in the active site |
-, 637609 |
2.5.1.7 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine |
intramolecular general acid catalysis through protonation of the bridging oxygen of the phosphate |
658965 |
2.5.1.7 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine |
Lys22 is located near the active site and involved in substrate binding |
-, 637603 |
2.5.1.7 | phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine |
mechanism |
-, 637597, 637602, 637605, 637608 |