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Results 1 - 3 of 3
EC Number Reaction Commentary Reference
Show all pathways known for 3.5.4.3Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.3guanine + H2O = xanthine + NH3 - -
Show all pathways known for 3.5.4.3Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.3guanine + H2O = xanthine + NH3 catalytic mechanism, quantum mechanical calculations using multilayered ONIOM and molecular dynamics study, the active-site residues of the enzyme do not affect the tautomeric state of guanine, Glu55 and Asp114 play important roles in proton shuttling in the reaction, proton transfer from a Zn-bound water to protonate Asp114, which can then transfer its proton to the N3 of the bound guanine, facilitating the nucleophilic attack on C2 of the guanine by the Zn-bound hydroxide to form a tetrahedral intermediate. Glu55 then transfers a proton from the Zn-hydroxide to the amino group of the reaction intermediate, ammonia leaves the active site, and xanthine is freed by the cleavage of the Zn-O2 bond 688614
Show all pathways known for 3.5.4.3Display the word mapDisplay the reaction diagram Show all sequences 3.5.4.3guanine + H2O = xanthine + NH3 mechanism 652554
Results 1 - 3 of 3