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EC Number
BRENDA No.
Title
Journal
Volume
Pages
Year
Organism
PubMed ID
1.1.98.3
763352
Development of 3,5-dinitrophenyl-containing 1,2,4-triazoles and their trifluoromethyl analogues as highly efficient antitubercular agents inhibiting decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase
J. Med. Chem.
62
8115-8139
2019
Mycobacterium tuberculosis
31393122
1.1.98.3
763352
Development of 3,5-dinitrophenyl-containing 1,2,4-triazoles and their trifluoromethyl analogues as highly efficient antitubercular agents inhibiting decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase
J. Med. Chem.
62
8115-8139
2019
Mycobacterium tuberculosis H37Rv
31393122
1.1.98.3
763349
Identification and profiling of hydantoins-A novel class of potent antimycobacterial DprE1 inhibitors
J. Med. Chem.
61
11221-11249
2018
Mycobacterium tuberculosis
30500189
1.1.98.3
763349
Identification and profiling of hydantoins-A novel class of potent antimycobacterial DprE1 inhibitors
J. Med. Chem.
61
11221-11249
2018
Mycobacterium tuberculosis H37Rv
30500189
1.1.98.3
740842
4-aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity
J. Med. Chem.
57
5419-5434
2014
Mycobacterium tuberculosis
24871036
1.1.98.3
720840
Analogous mechanisms of resistance to benzothiazinones and dinitrobenzamides in Mycobacterium smegmatis
PLoS ONE
6
e26675
2011
Mycolicibacterium smegmatis
22069462
1.1.98.3
719666
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-beta-D-ribofuranose 2'-oxidase DprE1
J. Am. Chem. Soc.
134
912-915
2012
Mycolicibacterium smegmatis
22188377
1.1.98.3
719647
Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-beta-D-ribose 2-epimerase DprE1 of Mycobacterium tuberculosis
J. Am. Chem. Soc.
132
13663-13665
2010
Mycobacterium tuberculosis
20828197
1.1.98.3
719647
Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-beta-D-ribose 2-epimerase DprE1 of Mycobacterium tuberculosis
J. Am. Chem. Soc.
132
13663-13665
2010
Mycobacterium tuberculosis H37Rv
20828197
1.1.98.3
739867
Characterization of DprE1-mediated benzothiazinone resistance in Mycobacterium tuberculosis
Antimicrob. Agents Chemother.
60
6451-6459
2016
Mycobacterium tuberculosis
27527085
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