EC Number   |
Expression |
Reference |
|---|
    1.5.1.2 | down |
PI3K inhibition significantly reduces PYCR1 mRNA and protein expression. Nutrient stress induced by glucose deprivation also regulates PYCR1 expression |
762610 |
| 1.5.1.2 | down |
upregulated micro-RNA miR-23b* in renal cancer is an important regulator of POX. Ectopic overexpression of miR-23b* in normal renal cells results in striking downregulation of POX, whereas POX expression increases markedly when endogenous miR-23b* is knocked down by its antagomirs in renal cancer cells |
713158 |
| 1.5.1.2 | up |
in a mass spectrometry-based screening of metabolites in tissue sections from 256 esophageal squamous cell carcinoma (ESCC) patients, a significant upregulation of L-proline metabolism is found in the cancer region compared to the normal epithelium and muscle regions. Immunohistochemistry staining of the ESCC tissue sections identifies PYCR2 as the most enriched metabolic enzyme in the cancer region, consistent with increased L-proline found in the same tissue region |
762678 |
| 1.5.1.2 | up |
oxidized low-density lipoproteins upregulate proline oxidase through nuclear receptor peroxisome proliferator-activated receptor gamma |
711685 |
