EC Number   |
Expression |
Reference |
|---|
    1.6.5.2 | more |
basal expression of NQO1 and NADPH cytochrome P450 oxidoreductase is comparable in isolated islets and liver |
746535 |
| 1.6.5.2 | more |
upon acute treatment with sulforaphane, increased GSTM1, NQO1, HO-1, and Gclc mRNA transcript levels are observed in adult liver, but no change in NQO1 activity |
746415 |
| 1.6.5.2 | up |
after 48 h of exposure, 2,3-dehydrosilydianin at concentrations of 25 microM and higher significantly elevates the activity of NQO1 in murine hepatoma Hepa1c1c7 cells. 2,3-dehydrosilydianin causes the accumulation of Nrf2 and significantly induces the expression of the Nqo1 gene at both the mRNA and protein levels |
744951 |
| 1.6.5.2 | up |
docosahexaenoic acid, DHA, activates transcription factor Nrf2, possibly through modification of a critical Keap1 cysteine288 residue and protein kinase delta-mediated phosphorylation of Nrf2, leading to upregulation of heme oxygenase HO-1 and NQO1 expression |
745826 |
| 1.6.5.2 | up |
expressed in cultures grown under both nitrogen-sufficient and nitrogen-limiting conditions |
741669 |
| 1.6.5.2 | up |
expression increases during growth in ethanol-sulfate, and to a less extent during pyruvate fermentation |
-, 742382 |
| 1.6.5.2 | up |
in sub-chronic studies upon oral exposure to sulphoraphane for 30 days a 2- to 3fold increase in GSTM1, Gclc and NQO1 transcript levels, and a 2fold increase in NQO1 activity in adult livers is observed |
746415 |
| 1.6.5.2 | up |
leflunomide elicits significant induction of pulmonary CYP1A1 and NQO1 expression in neonatal mice. The dose at which leflunomide increases NQO1 is significantly higher than that required to induce CYP1A1 enzyme. Leflunomide also enhances hepatic CYP1A1, 1A2 and NQO1 expression in wild-type mice and fails to induce these enzymes in aryl hydrocarbon receptor-null mice |
744242 |
| 1.6.5.2 | up |
NQO1 is inducible |
725060 |
| 1.6.5.2 | up |
NQO1, but not NADPH cytochrome P450 oxidoreductase , is strongly induced in pancreatic beta-cells exposed to menadione |
746535 |
