evolution
galactitol 2-dehydrogenase belongs to the protein subfamily of short-chain dehydrogenases/reductases
evolution
LadB belongs to the medium-chain dehydrogenases
malfunction
deletion of ladB in Aspergillus niger results in growth arrest on galactitol and significantly slower growth on D-galactose supplemented with a small amount of D-xylose. D-Galactose alone cannot be utilised by Aspergillus niger and the addition of D-xylose stimulates growth on D-galactose via transcriptional activation of the D-xylose-inducible reductase gene, xyrA
metabolism
LadB catalyzes a step in the oxido-reductive pathway for D-galactose catabolism in filamentous fungi, overview
more
homology modeling and sequence analysisA , overview. The active site contains residues Asn119,Ser147, Tyr162, and Lys166 which are conserved in short-chain dehydrogenases/reductases
