EC Number   |
General Information  |
Reference |
|---|
    1.1.1.248 | evolution |
the enzyme is a member of the short chain dehydrogenase/reductase family of enzymes. The nicotinamide moiety and the substrate-binding pocket are covered by a loop (residues 265-279), on top of which lies a large flap-like domain (residues 105-140). This configuration appears to be a combination of the two common structural themes found in other members of the short chain dehydrogenase/reductase family. |
725460 |
| 1.1.1.248 | malfunction |
reduced SalR protein levels correlate with lower morphine levels and a substantial increase in the accumulation of salutaridine. Morphine biosynthesis can be perturbed at each of the six final steps |
720707 |
| 1.1.1.248 | metabolism |
in the biosynthetic pathway for morphine and codeine, salutaridine is reduced to salutaridinol by salutaridine reductase using NADPH as coenzyme |
725460 |
| 1.1.1.248 | metabolism |
the enzyme catalyzes a step in the morphinan alkaloid pathway, benzylisoquinoline alkaloid biosynthesis in opium poppy from (R)-reticuline to morphine overview. Morphine biosynthesis can be perturbed at each of the six final steps |
720707 |
| 1.1.1.248 | more |
modeling of substrate binding and conformation of bound salutaridine, interactions between SalR and its substrate and coenzyme, overview |
725460 |
