  1.1.1.292 | physiological function |
nonencapsulated Streptococcus pneumoniae bacteria are successful colonizers of the human nasopharynx and often possess genes aliB-like ORF 1 and 2 in place of capsule genes. AliB-like ORF 2 binds peptide FPPQSV, found in Prevotella species, resulting in enhanced colonization. 1,5-anhydro-D-fructose reductase is a metabolic enzyme of an alternative starch and glycogen degrading pathway found in many organisms, in both transcriptomic and proteomic data. The peptide increases expression of genes involved in release of host carbohydrates, carbohydrate uptake and carbohydrate metabolism. AliB-like ORF 2 confers an advantage in colonization by enhancing carbohydrate metabolism resulting in a boost in growth. This may explain the widespread presence of aliB-like ORF 2 in the nonencapsulated pneumococcal population in the human nasopharynx. Peptide FPPQSV is absolutely required for induction of enzyme 1,5-anhydro-D-fructose reductase (AFR) via AliB-like ORF 2, no activity without the peptide |
-, 762866 |
