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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 1.1.1.325metabolism sepiapterin reductase (SPR) catalyzes the final steps of tetrahydrobiopterin (BH4) biosynthesis 739887
Display the reaction diagram Show all sequences 1.1.1.325more alignment of amino acid sequences near the N-termini of sepiapterin reductases from various sources, overview 286026
Display the reaction diagram Show all sequences 1.1.1.325physiological function sepiapterin reductase (SPR) catalyzes the final steps of tetrahydrobiopterin (BH4) biosynthesis. BH4 is an essential cofactor for aromatic acid hydroxylases and nitric oxide synthase. BH4 deficiency causes endothelial dysfunction, such as hypertension, atherosclerosis, diabetes, etc. 739887
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