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Results 1 - 7 of 7
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.370evolution the enzyme belongs to the glucose-fructose oxidase/inositol dehydrogenase/microbial rhizopine-catabolizing (GFO/IDH/MocA) family 763619
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.370malfunction inactivation of iolX impairs growth with scyllo-inositol as the carbon source -, 712965
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.370metabolism scyllo-inositol dehydrogenase is involved in the first step in the pathway that oxidizes L-glucose to produce L-glucono-1,5-lactone with concomitant reduction of NAD+ dependent manner 763619
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.370metabolism the enzyme is involved in the inositol metabolic pathway in Bacillus subtilis, organization of the relevant genes, overview -, 762863
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.370more in addition to the conserved catalytic residues (Lys106, Asp191, and His195), another residue, His318, located in the loop region of the adjacent subunit, is involved in substrate recognition. The Arg178 residue located in the flexible loop at the entrance of the catalytic site is also involved in substrate recognition, and plays an important role in accepting both L-glucose and inositols as substrates. The corresponding distances in the myo-inositol and scyllo-inosose complexes are 2.8 A and 3.1 A, respectively, and the relative positions of NAD+ and the inositols are the same as those seen in the lactone complex 763619
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.370physiological function Bacillus subtilis is able to utilize at least three inositol stereoisomers as carbon sources, myo-, scyllo-, and D-chiro-inositol (MI, SI, and DCI, respectively). NAD+-dependent SI dehydrogenase is responsible for SI catabolism. IolQ is a transcriptional repressor of iolX. Expression of gene iolQ is required to regulate gene iolX transcription in response to scyllo-inositol, identification of the two IolQ-binding sites within the iolX promoter region -, 762863
Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.370physiological function the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA -, 712965
Results 1 - 7 of 7