EC Number |
General Information |
Reference |
---|
1.1.1.370 | evolution |
the enzyme belongs to the glucose-fructose oxidase/inositol dehydrogenase/microbial rhizopine-catabolizing (GFO/IDH/MocA) family |
763619 |
1.1.1.370 | malfunction |
inactivation of iolX impairs growth with scyllo-inositol as the carbon source |
-, 712965 |
1.1.1.370 | metabolism |
scyllo-inositol dehydrogenase is involved in the first step in the pathway that oxidizes L-glucose to produce L-glucono-1,5-lactone with concomitant reduction of NAD+ dependent manner |
763619 |
1.1.1.370 | metabolism |
the enzyme is involved in the inositol metabolic pathway in Bacillus subtilis, organization of the relevant genes, overview |
-, 762863 |
1.1.1.370 | more |
in addition to the conserved catalytic residues (Lys106, Asp191, and His195), another residue, His318, located in the loop region of the adjacent subunit, is involved in substrate recognition. The Arg178 residue located in the flexible loop at the entrance of the catalytic site is also involved in substrate recognition, and plays an important role in accepting both L-glucose and inositols as substrates. The corresponding distances in the myo-inositol and scyllo-inosose complexes are 2.8 A and 3.1 A, respectively, and the relative positions of NAD+ and the inositols are the same as those seen in the lactone complex |
763619 |
1.1.1.370 | physiological function |
Bacillus subtilis is able to utilize at least three inositol stereoisomers as carbon sources, myo-, scyllo-, and D-chiro-inositol (MI, SI, and DCI, respectively). NAD+-dependent SI dehydrogenase is responsible for SI catabolism. IolQ is a transcriptional repressor of iolX. Expression of gene iolQ is required to regulate gene iolX transcription in response to scyllo-inositol, identification of the two IolQ-binding sites within the iolX promoter region |
-, 762863 |
1.1.1.370 | physiological function |
the enzyme is part of a scyllo-inositol degradation pathway leading to acetyl-CoA |
-, 712965 |