EC Number   |
General Information |
Reference |
|---|
   1.11.1.24 | drug target |
the enzyme is a possible drug target for the development of strategies to control Babesia microti infection |
756839 |
| 1.11.1.24 | drug target |
the enzyme is unsuitable as a diagnostic antigen for baylisascariasis in pandas |
756868 |
| 1.11.1.24 | malfunction |
Bcp null mutant grows more slowly than its wild type in aerobic culture and shows the hypersensitivity toward various oxidants such as H2O2, tert-butyl hydroperoxide, and linoleic acid hydroperoxide |
-, 754059 |
| 1.11.1.24 | malfunction |
the lack of prxQ gene results in enhanced cell sensitivity, increased ROS accumulation, and elevated protein carbonylation levels under adverse stress conditions |
-, 758163 |
| 1.11.1.24 | metabolism |
the enzyme plays an important role in the antioxidant defense system (peroxide-scavenging system) in an anaerobic archaeon Pyrococcus horikoshii |
-, 745231 |
| 1.11.1.24 | more |
although this Tp peroxiredoxin closely resembles AhpC-like peroxidoxins, Treponema pallidum lacks AhpF, the typical reductant for such enzymes. Functionally, TpAhpC resembles largely eukaryotic, nonAhpC typical 2-Cys Prx proteins in using thioredoxin as an efficient electron donor and exhibiting broad specificity toward hydroperoxide substrates |
713425 |
| 1.11.1.24 | more |
regulation of BiPrx1 and BiTPx1 expression via reduction of transcript levels in the fat body with RNA interference, overview. RNAi-induced BiPrx1 knockdown in worker bees causes upregulated expression of BiTPx1. Reciprocally, BiTPx1 RNAi knockdown causes upregulation of BiPrx1 expression in the fat body |
711782 |
| 1.11.1.24 | more |
the fish Prx 2 contains the GGLG motif associated with the sensitivity of eukaryotic typical 2-Cys Prx proteins to overoxidation and consequent inactivation by H2O2 |
711785 |
| 1.11.1.24 | physiological function |
AhpC of Leptospira interrogans is a thioredoxin-dependent peroxiredoxin that plays an important role in protecting Leptospira interrogans against oxidative stress in macrophages |
756490 |
| 1.11.1.24 | physiological function |
CsTPX3 is involved in the defense against oxidative stress |
755908 |
