EC Number   |
General Information |
Reference |
|---|
   1.14.11.11 | evolution |
the enzyme belongs to the 2-oxoglutarate-depedent dioxygenase family |
726207 |
| 1.14.11.11 | evolution |
the enzyme is a member of the 2-oxoglutarate-dependent dioxygenase family |
726202 |
| 1.14.11.11 | metabolism |
hyoscyamine 6b-hydroxylase catalyzes two consecutive oxidation reactions. The first reaction is the hydroxylation of hyoscyamine to 6beta-hydroxyhyoscyamine and the second is epoxidation of 6beta-hydroxyhyoscyamine yielding scopolamine, EC 1.14.11.14, the final metabolite in the tropane alkaloid biosynthetic pathway |
726202 |
| 1.14.11.11 | metabolism |
hyoscyamine 6b-hydroxylase, H6H, is an important enzyme in the biosynthesis of tropane alkaloids. It catalyzes the hydroxylation of hyoscyamine to give 6beta-hydroxyhyoscyamine and its epoxidation in the biosynthetic pathway leading to scopolamine. The DmrH6H epoxidase activity Is low compared to the hydroxylase activity |
713300 |
| 1.14.11.11 | metabolism |
hyoscyamine 6beta-hydroxylase converts hyoscyamine to scopolamine in the last step of scopolamine biosynthetic pathway |
724637 |
| 1.14.11.11 | metabolism |
the enzyme catalyzes the hydroxylation of (-)-hyoscyamine and the subsequent epoxidation of 6beta-hydroxyhyoscyamine to form scopolamine, a natural alkaloid |
742949 |
| 1.14.11.11 | metabolism |
the enzyme catalyzes the last two steps in the scopolamine biosynthetic pathway performing two consecutive oxidation reactions including the hydroxylation of hyoscyamine to 6beta-hydroxyhyoscyamine and the epoxidation of 6beta-hydroxyhyoscyamine to yield scopolamine. Biosynthesis pathway of tropane alkaloids, overview |
726207 |
| 1.14.11.11 | metabolism |
the enzyme is involved in biosynthesis pathway of tropane alkaloids catalyzing two oxidation steps to form scopolamine from hyoscyamine, overview, cf. EC 1.14.11.14 |
725946 |
| 1.14.11.11 | more |
the nitrogen atom in the tropane ring of L-hyoscyamine plays an important role in substrate recognition. Proposed mechanism of epoxidation catalyzed by H6H, overview |
724556 |
| 1.14.11.11 | more |
the transcript level of H6H increased under chromium treatment. This treatment also increases hyoscyamine and scopolamine contents, phenotype with decreased the growth parameters (weights and lengths of the plantlets) and chlorophyll contents and increased proline contents, overview |
726202 |
