EC Number   |
General Information |
Reference |
|---|
    1.14.11.8 | evolution |
the enzyme belongs to the family of 2-oxoglutarate (2OG)-dependent oxygenases |
744681 |
| 1.14.11.8 | evolution |
the enzyme belongs to the family of 2-oxoglutarate (2OG)-dependent oxygenases. Members of Fe(II) and 2-oxoglutarate-dependent oxygenases catalyze stereoselective hydroxylations of unactivated C-H bonds in various (bio)molecules, including proteins, DNA, and small molecule metabolites |
745961 |
| 1.14.11.8 | evolution |
the enzyme belongs to the non-heme Fe(II) and 2-oxoglutarate dependent oxygenases |
744678 |
| 1.14.11.8 | metabolism |
the enzyme catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. Carnitine biosynthesis patway, overview |
744681 |
| 1.14.11.8 | metabolism |
the enzyme catalyzes the first step in the biosynthesis of carnitine |
691166 |
| 1.14.11.8 | metabolism |
the enzyme catalyzes the first step in the biosynthesis of carnitine, i.e. L-3-hydroxy-4-N-N-N-trimethylaminobutyrate. Lysine in protein peptide linkages undergoes methylation of the 1-amino group to yield trimethyllysine, TML, which is released upon protein degradation. Muscle is the major source of TML. The released TML is further oxidised to gamma-butyrobetaine by the action of trimethyllysine dioxygenase, 3-hydroxy-N-trimethyllysine aldolase and 4-N-trimethylaminobutyraldehyde dehydrogenase |
697027 |
| 1.14.11.8 | metabolism |
trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nepsilon-trimethyllysine in the first step of carnitine biosynthesis |
744678 |
| 1.14.11.8 | metabolism |
trimethyllysine hydroxylase (TMLH) catalyses C-3 hydroxylation of Nepsilon-trimethyllysine in the first step of carnitine biosynthesis in humans |
745958 |
| 1.14.11.8 | metabolism |
trimethyllysine hydroxylase (TMLH) catalyses the first step in carnitine biosynthesis, the conversion of N6,N6,N6-trimethyl-L-lysine to 3-hydroxy-N6,N6,N6-trimethyl-L-lysine |
746366 |
| 1.14.11.8 | metabolism |
trimethyllysine hydroxylase (TMLH) is involved in the first step of the physiologically important carnitine biosynthesis pathway. The enzyme catalyzes C-3 hydroxylation of (2S)-Nepsilon-L-trimethyllysine, to produce 3-hydroxy-Nepsilon-L-trimethyllysine, which then undergoes three additional enzymatic steps to the final L-carnitine |
745961 |
