EC Number   |
General Information |
Reference |
|---|
   1.14.13.127 | evolution |
MhpAK-12 and its putative homologues belong to taxa that are phylogenetically distant from functionally identified FAD-containing monooxygenases (hydroxylases) |
-, 763969 |
| 1.14.13.127 | malfunction |
gene deletion and complementation showed that mhpA is vital for its growth on 3-(3-hydroxyphenyl)propanoate (3HPP), but the mhpA deletion strain is still able to grow on 3-(2,3-dihydroxyphenyl)propionate (DHPP), the hydroxylation product is transformed from 3HPP by MhpAK-12. MhpAK-12 has approximately an extra 150 residues at its C-terminus in comparison to its close homologues, but its truncated versions MhpAK-12_400 and MhpAK-12_480 (with 154 and 74 residues deleted from the C-terminus, respectively) both lose their activities |
-, 763969 |
| 1.14.13.127 | metabolism |
proposed pathway for 3-(3-hydroxyphenyl)propanoate (3HPP) degradation by Escherichia coli strain K-12 via the meta pathway, together with the catabolic reactions catalyzed by the mhp gene products in vivo, overview |
-, 763969 |
| 1.14.13.127 | more |
the 154 amino acid residues in the C-terminus of MhpAK-12 play an important role in its hydroxylation activity of the enzyme |
-, 763969 |
