EC Number   |
General Information |
Reference |
|---|
   1.14.13.167 | malfunction |
the npcA mutant strain SDA1 completely loses the ability to grow on 4-nitrophenol as the sole carbon source |
-, 659045 |
| 1.14.13.167 | metabolism |
the enzyme is involved in 3-methyl-4-nitrophenol degradation in Burkholderia sp. strain SJ98, phathway overview. Methyl-1,4-benzoquinone (MBQ) and methylhydroquinone (MHQ), rather than catechol proposed previously, are identified as the intermediates before ring cleavage during 3-methyl-4-nitrophenol degradation by Burkholderia sp. strain SJ98. By sequential catalysis assays, PnpCD, PnpE, and PnpF are likely involved in the further pathway of 3-methyl-4-nitrophenol catabolism |
742581 |
| 1.14.13.167 | metabolism |
the enzymes responsible for 4-nitrophenol catabolism are also likely to be involved in 2-chloro-4-nitrophenol degradation. Catabolism of 2-chloro-4-nitrophenol and of 4-nitrophenolshare the same gene cluster in strain SJ98 |
741687 |
| 1.14.13.167 | physiological function |
2-chloro-4-nitrophenol serves as a substrate for the 4-monooxygenase PnpA, but wild-type is unable to utilize 2-chloro-4-nitrophenol. Transcriptional regulator PnpR variant S6C drives the 4-nitrophenol-independent expression of PnpA and PnpB operons in an almost constitutive manner and allows higher levels of induction upon addition of inducers. When the pnpRS6C allele is introduced into a PnpR-deleted mutant, the corresponding strain acquires the ability to grow on 2-chloro-4-nitrophenol but is still able to utilize 4-nitrophenol for growth |
764850 |
| 1.14.13.167 | physiological function |
para-nitrophenol 4-monooxygenase gene pnpA plays an essential role in 4-nitrophenol mineralization in strain Pseudomonas putida strain WBC-3 |
704288 |
| 1.14.13.167 | physiological function |
PnpA, a PNP 4-monooxygenase, is able to catalyze the monooxygenation of 2-chloro-4-nitrophenol to 2-chloro-1,4-benzoquinone. PnpB, a 1,4-benzoquinone reductase, has the ability to catalyze the reduction of 2-chloro-1,4-benzoquinone to chlorohydroquinone. Moreover, PnpB is also able to enhance PnpA activity in vitro in the conversion of 2-chloro-4-nitrophenol to 2-chloro-1,4-benzoquinone. Gene pnpA plays an essential role in the degradation of both 2-chloro-4-nitrophenol and 4-nitrophenol. Catabolism of 2-chloro-4-nitrophenol and of 4-nitrophenolshare the same gene cluster in strain SJ98 |
741687 |
| 1.14.13.167 | physiological function |
PnpA, a PNP 4-monooxygenase, is able to catalyze the monooxygenation of 3-methyl-4-nitrophenol to 3-methyl-1,4-benzoquinone. PnpB, a 1,4-benzoquinone reductase, has the ability to catalyze the reduction of 3-methyl-1,4-benzoquinone to methylhydroquinone. Moreover, PnpB is also able to enhance PnpA activity in vitro in the conversion of 3-methyl-4-nitrophenol to 3-methyl-1,4-benzoquinone |
742581 |
| 1.14.13.167 | physiological function |
PnpA1, a PNP 4-monooxygenase, is able to catalyze the monooxygenation of 2-chloro-4-nitrophenol to 2-chloro-1,4-benzoquinone |
-, 741687 |
