EC Number   |
General Information |
Reference |
|---|
   1.14.14.86 | evolution |
the enzyme belong to the CYP701A subfamily |
744583 |
| 1.14.14.86 | metabolism |
function in the early steps of gibberellin biosynthesis |
696834 |
| 1.14.14.86 | metabolism |
kaurene oxidase is a multifunctional cytochrome P450 catalysing three sequential oxidations in gibberellin phytohormone biosynthesis. These serve to transform the C4alpha methyl of the ent-kaurene olefin intermediate into the carboxylic acid moiety of ent-kauren-19-oic acid |
-, 711149 |
| 1.14.14.86 | metabolism |
oxidation of ent-kaurene to ent-kaurenoic acid is a common process in gibberellin biosynthesis by vascular plants and production of gibberellin-like compounds by nonvascular plants |
745244 |
| 1.14.14.86 | metabolism |
oxidation of ent-kaurene to ent-kaurenoic acid is involved in gibberellin biosynthesis |
744583 |
| 1.14.14.86 | metabolism |
the enzyme catalyzes the three-step oxidation of the C4alpha methyl of the tetracyclic diterpene intermediate ent-kaurene to form ent-kaurenoic acid as an early step in gibberellin (GA) biosynthesis, gibberellin phytohormone biosynthesis, pathway overview |
744999 |
| 1.14.14.86 | metabolism |
the enzyme is involved in the in the gibberellin biosynthetic pathway, it catalyzes the three-step oxidation of ent-kaurene to ent-kaurenoic acid |
746448 |
| 1.14.14.86 | more |
a modular metabolic engineering system is used in a combinatorial biosynthetic approach to detect substrates of ent-kaurene oxidase, overview |
746311 |
| 1.14.14.86 | more |
enzyme structur homology modeling and molecular docking, using the crystal structure of cytochrome P450 monooxygenase CYP170A1 from Streptomyces coelicolor, PDB ID 3DBG, as template. Key residue Leu387 contributes to the formation of 16alpha-hydroxy-ent-kaurenoic acid, most likely by forming hydrogen bonds with the hydroxyl group of 16alpha-hydroxy-ent-kaurane, multifunctional nature of kaurene oxidase catalysis, overview |
744999 |
| 1.14.14.86 | physiological function |
in the gibberellin biosynthetic pathway. CPSent catalyzes the cyclization of geranylgeranyl diphosphate to ent-copalyl diphosphate, which is converted to ent-kaurene by kaurene synthase. Then, kaurene oxidase catalyzes the three-step oxidation of ent-kaurene to ent-kaurenoic acid |
746448 |
