EC Number   |
General Information |
Reference |
|---|
    1.2.7.4 | evolution |
phylogenomic study of monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS) in over 6400 archaeal and bacterial genomes. The CODH/ACS complex displays astounding conservation and vertical inheritance over geological times. Rare intradomain and interdomain transfer events might tie into important functional transitions, including the acquisition of CODH/ACS in some archaeal methanogens not known to fix carbon, the tinkering of the complex in a clade of model bacterial acetogens, or emergence of archaeal-bacterial hybrid complexes. Presence of a CODH/ACS complex with at least four subunits in the last universal common ancestor. Different scenarios on the possible role of ancestral CODH/ACS are discussed |
758239 |
| 1.2.7.4 | metabolism |
carbon monoxide dehydrogenase/acetyl-CoA synthase (CODH/ACS) is a five-subunit enzyme complex responsible for the carbonyl branch of the Wood-Ljungdahl (WL) pathway, considered one of the most ancient metabolisms for anaerobic carbon fixation |
758239 |
| 1.2.7.4 | physiological function |
functional expression of the CODH/acetyl-CoA synthase ACS complex in Clostridium acetobutylicum, engineered to express CODH alone or together with the ACS. Both strains exhibit CO2 reduction and CO oxidation activities. CODH uses a native C. acetobutylicum ferredoxin as an electron carrier for CO2 reduction. Heterologous CODH activity depends on actively growing cells and requires the addition of nickel, which is inserted into CODH without the need to express the native Ni insertase protein. Increasing CO concentrations in the gas phase inhibit CODH activity and alter the metabolite profile of the CODH-expressing cells |
762635 |
| 1.2.7.4 | physiological function |
the enzyme is involved in autotrophic CO2 fixation, carbon monoxide dehydrogenase pathway |
-, 721441, 721443 |
