EC Number   |
General Information |
Reference |
|---|
    1.3.1.24 | drug target |
the enzyme (BVR-A) is a potential therapeutic target to prevent brain insulin resistance in Alzheimer disease |
763475 |
| 1.3.1.24 | malfunction |
impairment of biliverdin reductase-A (BVR-A) is an early event leading to brain insulin resistance in Alzheimer disease. Cells lacking the enzyme (BVR-A) develop insulin resistance if treated with insulin and can be recovered from insulin resistance only if treated with a BVR-A-mimetic peptide |
763475 |
| 1.3.1.24 | malfunction |
the loss of biliverdin reductase A results in the reduction of mitochondria number, decreased expression of markers of mitochondrial biogenesis, uncoupling, oxidation, and fusion, which paralleles reduced mitochondrial oxygen consumption. Biliverdin reductase A KO cells exhibit increased levels of ROS generation and decreased levels of superoxide dismutase mRNA expression |
762673 |
| 1.3.1.24 | malfunction |
using BVR siRNA, blocking generation of bilirubin, reverses the effect of hypoxia on enhancing cell survival and apoptotic protein (Bcl-2, procasepase-9, procasepase-3) expression, preventing nuclear shrinkage, DNA fragmentation and mitochondrial depolarization in starved pulmonary arterial smooth muscle cell, which are recovered by exogenous bilirubin. The inhibitory effect of bilirubin on pulmonary arterial smooth muscle cell apoptosis under hypoxic condition is blocked by the inhibitor of ERK1/2 pathway |
724921 |
| 1.3.1.24 | metabolism |
BVR is part of the heme oxygenase protection system, overview |
712793 |
| 1.3.1.24 | metabolism |
critical role for biliverdin reductase A in protecting against lipid accumulation and oxidative stress in hepatocytes which may serve as a future therapeutic target for non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) |
762673 |
| 1.3.1.24 | metabolism |
HIF-1alpha regulates the expression of BVR and other enzymes involved in oxidative stress response in lung macrophages, overview |
713359 |
| 1.3.1.24 | metabolism |
isoform BVRA interacts with components in both the PI3-kinase/Akt and the IRK/IRS/PI3-kinase/MAPK pathyway |
741460 |
| 1.3.1.24 | metabolism |
it is shown that the rates of sHO-1 (shortened form of heme oxygenase-1) metabolism in the presence and absence of BVR are equal |
724825 |
| 1.3.1.24 | metabolism |
key enzymes of the hemoglobin degradation cascade. Biliverdin reductase is probably also involved in protecting choroid plexus epithelial cells and the blood-cerebrospinal fluid barrier from the negative effects of subarachnoid hemorrhage |
763065 |
