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EC Number General Information Commentary Reference
Show all pathways known for 1.3.1.48Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.48evolution the three human PG reductases are zinc-independent members of the medium-chain dehydrogenase/reductase (MDR) superfamily 744677
Show all pathways known for 1.3.1.48Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.48metabolism prostaglandins are lipid compounds derived from arachidonic acid by the action of cyclooxygenases, acting locally as messenger molecules in a wide variety of physiological processes, such as inflammation, cell survival, apoptosis, smooth muscle contraction, adipocyte differentiation, vasodilation and platelet aggregation inhibition. In the inactivating pathway of prostaglandins, the first metabolic intermediates are 15-keto-prostaglandins, which are further converted into 13,14-dihydro-15-keto-prostaglandins by different enzymes having 15-keto-prostaglandin reductase activity 744677
Show all pathways known for 1.3.1.48Display the word mapDisplay the reaction diagram Show all sequences 1.3.1.48physiological function prostaglandin E2, PGE2, has a short half-life in vivo because is rapidly oxidized to 15-ketoprostaglandins by the cytosolic enzyme 15-PGDH. PGE2 acts through EP2 and EP4 receptors to mediate regeneration and hematopoietic stem cell development via the Wnt signaling pathway. Wnt activation in stem cells requires PGE2, and the PGE2/Wnt interaction is a master regulator of vertebrate regeneration and recovery. PGE2 regulates vertebrate hematopoietic stem cell induction and engraftment 746356
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