EC Number   |
General Information |
Reference |
|---|
    1.5.1.21 | evolution |
enzyme Pyr2C reductase is a member of the ornithine cyclodeaminase/micro-crystallin superfamily and behaves similar to DkpA |
742531 |
| 1.5.1.21 | metabolism |
the enzyme is important in the L-pipecolate pathway, overview. Besides the pipecolate pathway, the enzyme is also involved in L-ornithine/L-glutamate/L-proline metabolism as well as sulfur-containing amino acid metabolism. There are two ways of lysine degradation, although the saccharopine pathway can be detected in the adult mouse brain, the pipecolate pathway greatly predominates in the adult mammalian brain. Pathway regulation, overview |
743355 |
| 1.5.1.21 | metabolism |
the enzyme is important in the L-pipecolate pathway, overview. Besides the pipecolate pathway, the enzyme is also involved in L-ornithine/L-glutamate/L-proline metabolism as well as sulfur-containing amino acid metabolism. There are two ways of lysine degradation, the saccharopine pathway and the pipecolate pathway, the latter dominates in the adult mammalian brain. Pathway regulation, overview |
743355 |
| 1.5.1.21 | metabolism |
the enzyme is not involved in the trans-3-hydroxy-L-proline pathway and the trans-4-hydroxy-L-proline pathway |
742531 |
| 1.5.1.21 | more |
enzymes that reduce DELTA1-pyrroline-5-carboxylate/DELTA1-piperideine-6-carboxylate (Pyr5C/P6C) are aldimine reductases, whereas enzymes that reduce DELTA1-pyrroline-2-carboxylate/DELTA1-piperideine-2-carboxylate (Pyr2C/P2C) are ketimine reductases |
743355 |
| 1.5.1.21 | physiological function |
CRYM has the ability to strongly bind thyroid hormones in an NADPH-dependent fashion. CRYM is also an enzyme, namely ketimine reductase, which catalyzes the NAD(P)H-dependent reduction of -C=N- (imine) double bonds of a number of cyclic ketimine substrates including sulfur-containing cyclic ketimines, the enzyme has a biological function in its degradative role as a DELTA1-piperideine-2-carboxylate (P2C) reductase in the pipecolate pathway of lysine metabolism. The pipecolate pathway is the main L-lysine degradation pathway in the adult brain. Potent regulation of ketimine reductase activity by thyroid hormones |
743355 |
