EC Number   |
General Information |
Reference |
|---|
    1.6.1.1 | evolution |
two pyridine nucleotide transhydrogenases: the energy-independent soluble pyridine nucleotide transhydrogenase (STH or UdhA) (EC 1.6.1.1) and the membrane-bound, energy-dependent pyridine nucleotide transhydrogenase (TH or PntAB) (EC 1.6.1.2). PntAB is widely distributed in the mitochondria and some bacteria, while STH is found only in certain Gammaproteobacteria and gram-positive bacteria |
725040 |
| 1.6.1.1 | physiological function |
in an UdhA knock-out strain, during growth on acetate, the expression of genes involved in the respiratory chain and Gad acid resistance system is inhibited. The deletion of UdhA significantly represses the expression of genes gadA, gadB, gadC, gadE, hdeA and hdeB are involved in glutamic acid resistance and results in low survival of the bacterium at a low pH of 4.9. UdhA is essential for NADH production which is important for the adaptive growth of Escherichia coli on acetate |
764252 |
| 1.6.1.1 | physiological function |
the soluble pyridine nucleotide transhydrogenase, STH, is an energy-independent flavoprotein that directly catalyzes hydride transfer between NAD(H) and NADP(H) to maintain homeostasis of these two redox cofactors |
725040 |
