EC Number   |
General Information |
Reference |
|---|
   1.6.5.9 | evolution |
three NADH dehydrogenases, two external rotenone-insensitive NADH:ubiquinone oxidoreductases (NDE1 and NDE2), and one internal rotenone-insensitive NADH:ubiquinone reductase (NDI1) |
725087 |
| 1.6.5.9 | malfunction |
strains carrying the deletion of NDH2 are completely viable |
-, 715708 |
| 1.6.5.9 | malfunction |
the induced RNAi cell line exhibits slower growth, decreased mitochondrial membrane potential and lower sensitivity of respiration to inhibitors. Mitochondrial membrane potential is altered in NDH2 knockdown. Growth phenotype of procyclic Trypanosoma brucei interfered against NDH2, overview |
-, 726096 |
| 1.6.5.9 | metabolism |
NDH2e-derived electrons are channelled to the cytochrome pathway |
714305 |
| 1.6.5.9 | more |
NdeA shows a pyridine nucleotide-disulfide oxidoreductase domain, a small NADH binding domain within a larger FAD binding domain at amino acid positions 226-334, and an EF-hand calcium-binding domain at amino acid positions 433-468 |
725087 |
| 1.6.5.9 | more |
NDH-2 structure analysis by circular dichroism and Fourier transform infrared spectroscopy using the recombinanatly expressed enzyme and modelling, overview |
724488 |
| 1.6.5.9 | more |
Ndi1 protein from Saccharomyces cerevisiae is a monotopic membrane protein, directed to the mitochondrial matrix. It is a peripheral membrane protein forming an intimate dimer, in which packing of the monomeric units within the dimer creates an amphiphilic membrane-anchor domain structure. Structures of the Ndi1NAD+ and Ndi1UQ2 complexes show overlapping binding sites for the NAD+ and quinone substrates |
726384 |
| 1.6.5.9 | more |
targeted expression of Ndi1 in fly neurons significantly increases lifespan without compromising fertility or physical activity. Expression of the yeast Ndi1 gene in Drosophila mitochondria leads to an increase in respiratory chain activity, overview |
723905 |
| 1.6.5.9 | physiological function |
Drosophila melanogaster expressing alternative NADH dehydrogenase NDX have 17-71% lifespan prolongation on media with different protein-to-carbohydrate ratios except NDX-expressing males that have 19% shorter lifespan than controls on a high protein diet. NDX-expressing flies are more resistant to 2,4-dichlorophenoxyacetic acid and alloxan, and to potassium iodate, and partially to sodium molybdate treatments. NDX-expressing flies are more sensitive to catechol and sodium chromate |
764248 |
| 1.6.5.9 | physiological function |
external rotenone-insensitive NADH:ubiquinone oxidoreductases (NDE1 and NDE2), and one internal rotenone-insensitive NADH:ubiquinone reductase (NDI1) are involved in farnesol resistance |
725087 |
